Evidence map›Paper›PMID 27785693›Full record

ArticleJournal of the American Society for Mass Spectrometry2017

A High Resolution/Accurate Mass (HRAM) Data-Dependent MS

Romel Dator, Andrea Carrà, Laura Maertens, Valeria Guidolin, Peter W Villalta, Silvia Balbo

Open access · greenAbstract read
In one paragraph

Article in Journal of the American Society for Mass Spectrometry, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.3field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 31 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. A high-specificity aniline-based mass tag for aldehyde detection.Rapid communications in mass spectrometry : RCM · 2022
    Article
  6. Quo vadis blood protein adductomics?Archives of toxicology · 2022
    Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Romel DatorMasonic Cancer Center, University of Minnesota, 2231 6th Street SE, Minneapolis, MN, 55455, USA.
Andrea CarràMasonic Cancer Center, University of Minnesota, 2231 6th Street SE, Minneapolis, MN, 55455, USA.
Laura MaertensMasonic Cancer Center, University of Minnesota, 2231 6th Street SE, Minneapolis, MN, 55455, USA.
Valeria GuidolinDepartment of Analytical Chemistry, University of Turin, Via Pietro Giuria 5, 10125, Turin, Italy.
Peter W VillaltaMasonic Cancer Center, University of Minnesota, 2231 6th Street SE, Minneapolis, MN, 55455, USA.
Silvia BalboMasonic Cancer Center, University of Minnesota, 2231 6th Street SE, Minneapolis, MN, 55455, USA. balbo006@umn.edu.
University of Minnesota · USUniversity of Turin · IT

Funding

Women's CancerP30CA077598 · NCI · UNIVERSITY OF MINNESOTA TWIN CITIES · PI Douglas Yee · 1998 to 2026
$100.4M
OCCUPATIONAL SAFETY AND HEALTH EDUCATION AND RESEARCH CENTERS (T42)T42OH008434 · OH · UNIVERSITY OF MINNESOTA TWIN CITIES · PI ARNOLD, SUSAN · 2005 to 2024
$31.3M
LTQ Orbitrap XL Mass SpectrometerS10RR024618 · NCRR · UNIVERSITY OF MINNESOTA · PI VILLALTA, PETER WILLIAM · 2009 to 2009
$500k
ACL HHS T42OH008434NCI NIH HHS P30 CA077598NCRR NIH HHS S10 RR024618NIOSH CDC HHS T42 OH008434
6 · The paper itself

Abstract

Reactive carbonyl compounds (RCCs) are ubiquitous in the environment and are generated endogenously as a result of various physiological and pathological processes. These compounds can react with biological molecules inducing deleterious processes believed to be at the basis of their toxic effects. Several of these compounds are implicated in neurotoxic processes, aging disorders, and cancer. Therefore, a method characterizing exposures to these chemicals will provide insights into how they may influence overall health and contribute to disease pathogenesis. Here, we have developed a high resolution accurate mass (HRAM) screening strategy allowing simultaneous identification and relative quantitation of DNPH-derivatized carbonyls in human biological fluids. The screening strategy involves the diagnostic neutral loss of hydroxyl radical triggering MS

Indexed as

Alcohol DrinkingAldehydesChromatography, High Pressure LiquidHumansKetonesPhenylhydrazinesSalivaSpectrometry, Mass, Electrospray Ionization2,4-dinitrophenylhydrazineAldehydesKetonesPhenylhydrazinesAldehydes/carbonyl compoundsDNPH-derivatizationExposomeHigh resolution accurate mass data-dependent MS3 neutral loss screeningRelative quantitation

Identifiers

PMID27785693
PMCPMC5772964
OpenAlexW2540832435

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.