ArticlePediatric nephrology (Berlin, Germany)2017
Neutrophil gelatinase-associated lipocalin: utility in urologic conditions.
Article in Pediatric nephrology (Berlin, Germany), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 3 syntheses or guidelines pooled it, 36 citations in OpenAlex.
- Biomarker for renal scarring screening in children with vesicoureteral reflux: a systematic review.Frontiers in pediatrics · 2025Pooled it
- Evaluation of diagnostic accuracy of urine neutrophil gelatinase-associated lipocalin in patients with symptoms of urinary tract infections: a meta-analysis.Frontiers in pediatrics · 2024Pooled it
- Neutrophil gelatinase-associated lipocalin as predictor of acute kidney injury in neonates with perinatal asphyxia: a systematic review and meta-analysis.European journal of pediatrics · 2018Pooled it
- Biomarkers innovation in urinary tract infections: Insights into pathophysiology, antibiotic resistance, and clinical applications.World journal of nephrology · 2025Review
- Serum neutrophil gelatinase associated Lipocalin as a novel biomarker for diagnosing acute pyelonephritis in adults.Scientific reports · 2025Article
- Biomarkers for urinary tract infection: present and future perspectives.Pediatric nephrology (Berlin, Germany) · 2024Review
- The diagnostic accuracy of urinary neutrophil gelatinase-associated lipocalin in assessing kidney function in severe hydronephrosis.Translational andrology and urology · 2024Article
- A Multimodal Fuzzy Approach in Evaluating Pediatric Chronic Kidney Disease Using Kidney Biomarkers.Diagnostics (Basel, Switzerland) · 2024Article
- The Role of Urinary NGAL in the Management of Primary Vesicoureteral Reflux in Children.International journal of molecular sciences · 2023Review
- Biomarkers for febrile urinary tract infection in children.Frontiers in pediatrics · 2023Article
- Urinary neutrophil gelatinase-associated lipocalin: a marker of urinary tract infection among febrile children.Clinical and experimental pediatrics · 2021Article
- Urinary biomarkers as point-of-care tests for predicting progressive deterioration of kidney function in congenital anomalies of kidney and urinary tract: trefoil family factors (TFFs) as the emerging biomarkers.Pediatric nephrology (Berlin, Germany) · 2021Article
- Biomarker evidence for distal tubular damage but cortical sparing in hospitalized diabetic patients with acute kidney injury (AKI) while on SGLT2 inhibitors.Renal failure · 2020Article
- Longitudinal kidney injury biomarker trajectories in children with obstructive uropathy.Pediatric nephrology (Berlin, Germany) · 2020Observational
- Validity of urine neutrophile gelatinase-associated lipocalin in children with primary vesicoureteral reflux.International urology and nephrology · 2020Article
- Associations of Plasma Neutrophil Gelatinase-associated Lipocalin, Anemia, and Renal Scarring in Children with Febrile Urinary Tract Infections.Journal of Korean medical science · 2020Article
- The role of urinary NGAL and serum cystatin C in assessing the severity of ureteropelvic junction obstruction in infants.Pediatric nephrology (Berlin, Germany) · 2020Article
- Correlation between urinary biomarker and organ failure in patients with sepsis and patients after esophagectomy: a prospective observational study.Journal of intensive care · 2020Article
- Molecular nephrology: types of acute tubular injury.Nature reviews. Nephrology · 2019Review
- Diagnostic accuracy of urine neutrophil gelatinase-associated lipocalin and urine kidney injury molecule-1 as predictors of acute pyelonephritis in young children with febrile urinary tract infection.Central-European journal of immunology · 2019Article
Corrections and comments
- Comment on
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Neutrophil gelatinase-associated lipocalin (NGAL) is best known as a non-invasive early marker of acute kidney injury (AKI). However, recent published reports have described additional utility of both plasma NGAL (pNGAL) and urine NGAL (uNGAL) in various pathologic conditions within the pediatric urinary tract, including urinary tract infection, vesicoureteral reflux (VUR), renal scarring, and obstructive uropathy. These two forms of NGAL have different applications related to their mechanisms of upregulation: pNGAL can serve as a marker of systemic inflammatory conditions, whereas uNGAL is specific for insults to the renal epithelium. Therefore, pNGAL has good predictive accuracy in systemic inflammation associated with pyelonephritis and renal damage, while uNGAL is an effective marker for identifying infection within the genitourinary environment as well as subclinical renal damage as a result of scarring or obstruction. Continued work should focus on the effect of trending NGAL values in patients with pyelonephritis, VUR, and hydronephrosis, to determine if longitudinal NGAL patterns have value in predicting adverse outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.