Evidence map›Paper›PMID 27785560›Full record

ArticleWorld journal of urology2017

Multiparametric magnetic resonance imaging for prostate cancer-a comparative study including radical prostatectomy specimens.

Liam Toner, Nathan Papa, Marlon Perera, Nikolas Katelaris, Mahesha Weerakoon, Kwang Chin, Laurence Harewood, Damien M Bolton, Nathan Lawrentschuk

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in World journal of urology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 2 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 2 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Review
  4. Article
  5. Article
  6. Review
  7. Review
  8. Review
  9. Prostate international · 2017
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Liam TonerUrology Unit, Department of Surgery, University of Melbourne, Melbourne, Australia. liammtoner@gmail.com.
Nathan PapaUrology Unit, Department of Surgery, University of Melbourne, Melbourne, Australia.
Marlon PereraUrology Unit, Department of Surgery, University of Melbourne, Melbourne, Australia.
Nikolas KatelarisUrology Unit, Department of Surgery, University of Melbourne, Melbourne, Australia.
Mahesha WeerakoonUrology Unit, Department of Surgery, University of Melbourne, Melbourne, Australia.
Kwang ChinDepartment of Radiology, Peter MacCallum Cancer Centre, Melbourne, Australia.
Laurence HarewoodUrology, Renal and Vascular Clinical Unit, Freemasons Campus, Epworth Healthcare, Melbourne, Australia.
Damien M BoltonUrology Unit, Department of Surgery, University of Melbourne, Melbourne, Australia.
Nathan LawrentschukUrology Unit, Department of Surgery, University of Melbourne, Melbourne, Australia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo evaluate the diagnostic and staging ability of multiparametric MRI (mpMRI) compared to radical prostatectomy (RP) specimens after dissemination of this technology to several centres. mpMRI is an evolving technique aiming to improve upon the diagnostic sensitivity of prostate biopsy for the diagnosis of prostate cancer. Differences in interpretation, expertise and application of mpMRI are responsible for the range of reported results.

methodsThis retrospective clinical study was conducted with consecutive patients through an electronic database of tertiary hospitals and adjacent private urology practices in Australia. Patients having undergone RP were assessed for the presence of a pre-operative mpMRI performed between 2013 and 2015 which was evaluated against the reference standard of the RP whole-mount specimen. MRI reports were evaluated using the Prostate Imaging Reporting and Data System (PI-RADS).

resultsIn our cohort of 152 patients, the sensitivity and specificity of mpMRI (PI-RADS ≥ 4) for prostate cancer (Gleason ≥ 4 + 3) detection were 83 and 47%, respectively. For the identification of extraprostatic disease, the sensitivity and specificity were 29 and 94%, respectively.

conclusionThese results represent a 'real-world' approach to mpMRI and appear comparable to other single-centre studies. MRI staging information should be interpreted in context with other risk factors for extraprostatic disease. mpMRI has a useful role as an adjunct for prostate cancer diagnosis and directing management towards improving patient outcomes.

Indexed as

AgedAustraliaBiopsy, NeedleCohort StudiesDatabases, FactualDisease-Free SurvivalHumansImmunohistochemistryMagnetic Resonance ImagingMaleMiddle AgedNeoplasm GradingPrognosisProstatectomyProstatic NeoplasmsRetrospective StudiesDiagnosisMagnetic resonance imagingProstatectomyProstatic neoplasms

Identifiers

PMID27785560

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.