ArticleDiabetologia2017
Rebranding asymptomatic type 1 diabetes: the case for autoimmune beta cell disorder as a pathological and diagnostic entity.
Article in Diabetologia, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 32 citations in OpenAlex.
- The countdown to type 1 diabetes: when, how and why does the clock start?Diabetologia · 2023Review
- Gene Delivery of Manf to Beta-Cells of the Pancreatic Islets Protects NOD Mice from Type 1 Diabetes Development.Biomolecules · 2022Article
- Article
- Rapid Point-of-Care Test for Determination of C-Peptide Levels.Journal of diabetes science and technology · 2022Article
- Simplifying prediction of disease progression in pre-symptomatic type 1 diabetes using a single blood sample.Diabetologia · 2021Article
- Rheumatoid Arthritis Pathogenesis, Prediction, and Prevention: An Emerging Paradigm Shift.Arthritis & rheumatology (Hoboken, N.J.) · 2021Review
- Exosomes and Their Noncoding RNA Cargo Are Emerging as New Modulators for Diabetes Mellitus.Cells · 2019Review
- Continuous Glucose Monitoring Predicts Progression to Diabetes in Autoantibody Positive Children.The Journal of clinical endocrinology and metabolism · 2019Article
- The challenge of modulating β-cell autoimmunity in type 1 diabetes.The lancet. Diabetes & endocrinology · 2019Review
- Screening for type 1 diabetes: are we nearly there yet?Diabetologia · 2019Article
- Islet Microvasculature Alterations With Loss of Beta-cells in Patients With Type 1 Diabetes.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2019Article
- Understanding Pre-Type 1 Diabetes: The Key to Prevention.Frontiers in endocrinology · 2018Review
- The chromosome 6q22.33 region is associated with age at diagnosis of type 1 diabetes and disease risk in those diagnosed under 5 years of age.Diabetologia · 2018Article
- Clinical Applications of Regulatory T cells in Adoptive Cell Therapies.Cell & gene therapy insights · 2018Article
- Article
Corrections and comments
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Authors and funding
14 authors at 13 institutions in 5 countries.
Funding
Abstract
The asymptomatic phase of type 1 diabetes is recognised by the presence of beta cell autoantibodies in the absence of hyperglycaemia. We propose that an accurate description of this stage is provided by the name 'Autoimmune Beta Cell Disorder' (ABCD). Specifically, we suggest that this nomenclature and diagnosis will, in a proactive manner, shift the paradigm towards type 1 diabetes being first and foremost an immune-mediated disease and only later a metabolic disease, presaging more active therapeutic intervention in the asymptomatic stage of disease, before end-stage beta cell failure. Furthermore, we argue that accepting ABCD as a diagnosis will be critical in order to accelerate pharmaceutical, academic and public activities leading to clinical trials that could reverse beta cell autoimmunity and halt progression to symptomatic insulin-requiring type 1 diabetes. We recognize that there are both opportunities and challenges in the implementation of the ABCD concept but hope that the notion of 'asymptomatic autoimmune disease' as a disorder will be widely discussed and eventually accepted.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.