ArticleeNeuro
Activation of a Habenulo-Raphe Circuit Is Critical for the Behavioral and Neurochemical Consequences of Uncontrollable Stress in the Male Rat.
Article in eNeuro. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
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Who cites it
39 citing papers in PubMed.
- Dual regulatory mechanisms of the ZI-LHb circuit in SPS&S model mice: dissociable control of aversion and anxiety through distinct downstream targets.Molecular psychiatry · 2026Article
- Mesohabenular glutamatergic regulation of the consequences of uncontrollable stress.bioRxiv : the preprint server for biology · 2026Article
- Early life chronic stress-disrupted activity of the dorsal raphe nucleus selectively drives behavioral impairments.Communications biology · 2026Article
- Circuit-specific remodeling of synaptic co-transmission in stress-responsive networks.Animal cells and systems · 2026Review
- Chemogenetic inhibition of prefrontal cortex inputs to dorsal raphe reduces anxiety behaviors in male rat model of fetal alcohol spectrum disorder.Scientific reports · 2025Article
- Research progress on the neural circuits mechanisms of anxiety.Frontiers in neural circuits · 2025Review
- Chronic Social Defeat Stress Induces Pathway-Specific Adaptations at Lateral Habenula Neuronal Outputs.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Disfunction of dorsal raphe nucleus-hippocampus serotonergic-HTR3 transmission results in anxiety phenotype of Neuroplastin 65-deficient mice.Acta pharmacologica Sinica · 2024Article
- Ventral tegmental area glutamate neurons mediate nonassociative consequences of stress.Molecular psychiatry · 2024Article
- Article
- Hypothalamic neuronal outputs transmit sensorimotor signals at the onset of locomotor initiation.iScience · 2023Article
- Unravelling the Role of Habenula Subnuclei on Avoidance Response: Focus on Activation and Neuroinflammation.International journal of molecular sciences · 2023Article
- From helplessness to controllability: toward a neuroscience of resilience.Frontiers in psychiatry · 2023Review
- Prior stress and vasopressin promote corticotropin-releasing factor inhibition of serotonin release in the central nucleus of the amygdala.Frontiers in behavioral neuroscience · 2023Article
- Prenatal ethanol exposure causes anxiety-like phenotype and alters synaptic nitric oxide and endocannabinoid signaling in dorsal raphe nucleus of adult male rats.Translational psychiatry · 2022Article
- Article
- Reward ameliorates depressive-like behaviors via inhibition of the substantia innominata to the lateral habenula projection.Science advances · 2022Article
- Lateral habenula neurocircuits mediate the maternal disruptive effect of maternal stress: A hypothesis.Zoological research · 2022Review
- Neural circuits provide insights into reward and aversion.Frontiers in neural circuits · 2022Review
- Animal models for the study of depressive disorder.CNS neuroscience & therapeutics · 2021Review
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Authors and funding
7 authors.
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Abstract
Exposure to uncontrollable stress [inescapable tailshock (IS)] produces behavioral changes that do not occur if the stressor is controllable [escapable tailshock (ES)] an outcome that is mediated by greater IS-induced dorsal raphe nucleus (DRN) serotonin [5-hydroxytryptamine (5-HT)] activation. It has been proposed that this differential activation occurs because the presence of control leads to top-down inhibition of the DRN from medial prefrontal cortex (mPFC), not because uncontrollability produces greater excitatory input. Although mPFC inhibitory regulation over DRN 5-HT activation has received considerable attention, the relevant excitatory inputs that drive DRN 5-HT during stress have not. The lateral habenula (LHb) provides a major excitatory input to the DRN, but very little is known about the role of the LHb in regulating DRN-dependent behaviors. Here, optogenetic silencing of the LHb during IS blocked the typical anxiety-like behaviors produced by IS in male rats. Moreover, LHb silencing blocked the increase in extracellular basolateral amygdala 5-HT during IS and, surprisingly, during behavioral testing the following day. We also provide evidence that LHb-DRN pathway activation is not sensitive to the dimension of behavioral control. Overall, these experiments highlight a critical role for LHb in driving DRN activation and 5-HT release into downstream circuits that mediate anxiety-like behavioral outcomes of IS and further support the idea that behavioral control does not modulate excitatory inputs to the DRN.
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