ArticleFrontiers in Marine Science2014
An analysis of the sponge
Article in Frontiers in Marine Science, 2014. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
39 citing papers in PubMed, 70 citations in OpenAlex.
- Proposed Biosynthesis and Molecular Targets of Manzamine Alkaloids fromMarine drugs · 2026Article
- Manzamine-A: Unraveling the Chemical and Biological Tapestry of a Marine-Derived Drug Lead.Marine drugs · 2026Review
- On the Discorhabdins Leading to the Aleutianamine Ring System: A One-Step in Situ Transformation Characterized Through Computational and Experimental Studies and Its Implications on Biosynthesis, Synthesis, and Pharmacology.Angewandte Chemie (International ed. in English) · 2026Article
- Tides of Promise: Sponge-Derived Marine Natural Products in Southeast Asia.Molecules (Basel, Switzerland) · 2026Review
- A Structure-Based Deep Learning Framework for Correcting Marine Natural Products' Misannotations Attributed to Host-Microbe Symbiosis.Marine drugs · 2026Article
- Cytotoxicity evaluation and metabolomic profiling of Spheciospongia vagabunda-associated fungi corroborated by in silico studies.Scientific reports · 2025Article
- Article
- Manzamine A reduces androgen receptor transcription and synthesis by blocking E2F8-DNA interactions and effectively inhibits prostate tumor growth in mice.Molecular oncology · 2024Article
- Manzamine-A AltersJournal of natural products · 2024Article
- Animal Microbiomes as a Source of Novel Antibiotic-Producing Strains.International journal of molecular sciences · 2023Review
- Profiling Prokaryotic Communities and Aaptamines of Sponge Aaptos suberitoides from Tulamben, Bali.Marine biotechnology (New York, N.Y.) · 2023Article
- Development of a drug discovery approach from microbes with a special focus on isolation sources and taxonomy.The Journal of antibiotics · 2023Review
- Revisiting the manzamine biosynthetic hypothesis.Natural product reports · 2023Review
- Genome features and secondary metabolite potential of the marine symbiont Streptomyces sp. RS2.Archives of microbiology · 2023Article
- Marine-Based Candidates as Potential RSK1 Inhibitors: A Computational Study.Molecules (Basel, Switzerland) · 2022Article
- The Exploration of Microbial Natural Products and Metabolic Interaction Guided by Mass Spectrometry Imaging.Bioengineering (Basel, Switzerland) · 2022Review
- Cytoprotective Polyketides from Sponge-Derived FungusMolecules (Basel, Switzerland) · 2022Article
- Major environmental drivers determining life and death of cold-water corals through time.PLoS biology · 2022Article
- Antimalarial Natural Products.Progress in the chemistry of organic natural products · 2022Article
- Comparative Genomics of Thaumarchaeota From Deep-Sea Sponges Reveal Their Niche Adaptation.Frontiers in microbiology · 2022Article
Corrections and comments
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Authors and funding
13 authors at 5 institutions in 3 countries.
Funding
Abstract
Sponges have generated significant interest as a source of bioactive and elaborate secondary metabolites that hold promise for the development of novel therapeutics for the control of an array of human diseases. However, research and development of marine natural products can often be hampered by the difficulty associated with obtaining a stable and sustainable production source. Herein we report the first successful characterization and utilization of the microbiome of a marine invertebrate to identify a sustainable production source for an important natural product scaffold. Through molecular-microbial community analysis, optimization of fermentation conditions and MALDI-MS imaging, we provide the first report of a sponge-associated bacterium (
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.