ArticleGastroenterology research2013
Oral Administration of Interleukin-10 and Anti-IL-1 Antibody Ameliorates Experimental Intestinal Inflammation.
Article in Gastroenterology research, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed.
- Exploring the Potential of Micro-Immunotherapy in the Treatment of Periodontitis.Life (Basel, Switzerland) · 2024Review
- Inflammatory Response Modulation by Low-Dose Anti-inflammatory Drugs Treatment in anCurrent medicinal chemistry · 2024Article
- Article
- The Clinical and Biological Effects of Homeopathically Prepared Signaling Molecules: A Scoping Review.Homeopathy : the journal of the Faculty of Homeopathy · 2022Article
- Therapeutic and Prophylactic Use of Oral, Low-Dose IFNs in Species of Veterinary Interest: Back to the Future.Veterinary sciences · 2021Review
- Regulation of Inflammatory Reaction in Health and Disease.International journal of molecular sciences · 2021Review
- Oral delivery of anti-TNF antibody shielded by natural polyphenol-mediated supramolecular assembly for inflammatory bowel disease therapy.Theranostics · 2020Article
- Gut Microbiota and the Alteration of Immune Balance in Skin Diseases: From Nutraceuticals to Fecal Transplantation.Open access Macedonian journal of medical sciences · 2019Review
- Low Dose Medicine: theoretical background and scientific evidence.Italian journal of pediatrics · 2018Article
- Intestinal Epithelial Cells Regulate Gut Eotaxin Responses and Severity of Allergy.Frontiers in immunology · 2018Article
- Long-term treatment with low-dose medicine in chronic childhood eczema: a double-blind two-stage randomized control trial.Italian journal of pediatrics · 2017Article
- [Successful combination treatment for psoriasis with phototherapy and low-dose cytokines: A spontaneous, retrospective observational clinical study].Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete · 2015Observational
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo elucidate the effects of a solution containing interleukin-10 and anti-IL-1 antibody in modulating experimental intestinal inflammation.
methodsColitis was induced in BALB/c mice by oral administration of dextran sodium sulphate; mice were then treated with interleukin-10 plus anti-IL-1 antibody at low dosage. Transepithelial electrical resistance of isolated mouse colon and colon lengths were evaluated. Cytokines concentrations in organocultures supernatants and plasma samples were evaluated by Enzyme-Linked Immuno Sorbent Assay. Tight junction proteins were evaluated by immunofluorescence, respectively.
resultsOral administration of tested products restores intestinal barrier function during experimental intestinal inflammation in association with reduced levels of proinflammatory cytokines, increased interleukin-10 plasma concentrations and a tight junction architecture restoration.
conclusionObtained results may contribute to modelling an interesting strategy for the treatment of patients with inflammatory bowel diseases.
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