Evidence map›Paper›PMID 27785160›Full record

ArticlePharmacy practice

Prevalence and nature of off-label antibiotic prescribing for children in a tertiary setting: A descriptive study from Jordan.

Tareq L Mukattash, Wail A Hayajneh, Shorok M Ibrahim, Abeer Ayoub, Nehad Ayoub, Anan S Jarab, Maher Khdour, Ammar Almaaytah

Open access · diamondAbstract read
In one paragraph

Article in Pharmacy practice. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
4.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 24 citations in OpenAlex.

  1. Article
  2. An Audit on Pharmacists' Knowledge and Experience in Pediatric Care.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2022
    Article
  3. Systematic Review of Early Phase Pediatric Clinical Pharmacology Trials.The journal of pediatric pharmacology and therapeutics : JPPT : the official journal of PPAG · 2022
    Article
  4. Article
  5. Article
  6. Article
  7. Article
  8. Off-label use of tamoxifen in a Chinese tertiary care hospital.International journal of clinical pharmacy · 2019
    Article
  9. Article
  10. Perceptions and attitudes towards off-label dispensing for pediatric patients, a study of hospital based pharmacists in Jordan.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2018
    Article
  11. An audit on parental attitudes towards medicines used in children.Saudi pharmaceutical journal : SPJ : the official publication of the Saudi Pharmaceutical Society · 2018
    Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Tareq L MukattashDepartment of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology , Irbid ( Jordan ). tlmukattash@just.edu.jo.ORCID 0000-0003-0200-9845
Wail A HayajnehDepartment of Paediatrics, Faculty of Medicine, Jordan University of Science and Technology , Irbid ( Jordan ). wailh@just.edu.jo.
Shorok M IbrahimDepartment of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology , Irbid ( Jordan ). shorouk.ibraheem@hotmail.com.ORCID 0000-0002-2379-622X
Abeer AyoubDepartment of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology , Irbid ( Jordan ). amayoub@just.edu.jo.
Nehad AyoubDepartment of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology , Irbid ( Jordan ). nmayoub@just.edu.jo.
Anan S JarabDepartment of Clinical Pharmacy, Faculty of Pharmacy, Jordan University of Science and Technology , Irbid ( Jordan ), Anansalam10@yahoo.com.ORCID 0000-0003-2052-439X
Maher KhdourDepartment of Clinical Pharmacy, AlQuds University . Jerusalem ( Palestine ). mkhdour@pharm.alquds.edu.
Ammar AlmaaytahDepartment of Pharmaceutical Technology, Faculty of Pharmacy, Jordan University of Science and Technology , Irbid ( Jordan ). amalmaaytah@just.edu.jo.ORCID 0000-0002-7804-3313
Jordan University of Science and Technology · JOAl-Quds University · PS

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThe aim of the present study was to evaluate the use of off-label antibiotics in neonatal intensive care units (NICUs) and paediatric wards in Jordan.

methodsData of patients admitted to the neonatal intensive care units and paediatric wards in King Abdulla University Hospital were collected over an 8-week survey between May and July 2012. Data collected in this study included patients' age, weight, medical history, diagnosis and the details of antibiotics prescribed to each patient.

resultsThe study involved a total of 250 children (80 admitted to the NICU and 170 admitted to the wards). A total of 598 antibiotic prescriptions were issued for these patients (244 in NICUs and 354 in paediatricwards). The results of the present study show that off-label antibiotic prescribing to paediatric patients is very common. Off-label antibiotic prescribing to paediatric patients is related mostly to doses and indications, and rarely to age. The majority of admitted patients received at least one off-label antibiotic during their hospital stay.

conclusionThis study reveals the high prevalence of off-label use of antibiotic among paediatric children in Jordan. There is a serious need for robust and continuous educational programs to improve the awareness of paediatricians of guidelines surrounding the use of antibiotics in paediatric patients. Furthermore, true collaboration between paediatricians and clinical pharmacists towards safe and effective antibiotic prescribing in paediatric patients is crucial.

Indexed as

Anti-Bacterial AgentsChildDrug UtilizationInfantInpatientsJordanOff-Label Use

Identifiers

PMID27785160
PMCPMC5061516
OpenAlexW2516380322

What OpenQuestion holds

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LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.