ArticleClinical epigenetics2016
Intra-individual changes in DNA methylation not mediated by cell-type composition are correlated with aging during childhood.
Article in Clinical epigenetics, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.
- Prenatal medication exposure and epigenetic outcomes: a systematic literature review and recommendations for prenatal pharmacoepigenetic studies.Epigenetics · 2022Pooled it
- BMI change during childhood, DNA methylation change at TXNIP, and glucose change during midlife.Obesity (Silver Spring, Md.) · 2023Article
- Effects of pesticide exposure on oxidative stress and DNA methylation urinary biomarkers in Czech adults and children from the CELSPAC-SPECIMEn cohort.Environmental research · 2023Article
- Perfluoroalkyl substances influence DNA methylation in school-age children highly exposed through drinking water contaminated from firefighting foam: a cohort study in Ronneby, Sweden.Environmental epigenetics · 2022Article
- Ageing-associated changes in DNA methylation in X and Y chromosomes.Epigenetics & chromatin · 2021Article
- Levels of endocrine-disrupting chemicals are associated with changes in the peri-pubertal epigenome.Endocrine connections · 2020Article
- Predicting Carcinogenic Mechanisms of Non-Genotoxic Carcinogens via Combined Analysis of Global DNA Methylation and In Vitro Cell Transformation.International journal of molecular sciences · 2020Article
- Article
- DNA methylation changes in infants between 6 and 52 weeks.Scientific reports · 2019Article
- DNA Methylation Signatures of Breastfeeding in Buccal Cells Collected in Mid-Childhood.Nutrients · 2019Article
- Contribution of DNA methylation in chronic stress-induced cardiac remodeling and arrhythmias in mice.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Article
- Duration of breastfeeding is associated with leptin (LEP) DNA methylation profiles and BMI in 10-year-old children.Clinical epigenetics · 2019Article
- Best practices in DNA methylation: lessons from inflammatory bowel disease, psoriasis and ankylosing spondylitis.Arthritis research & therapy · 2019Review
- Identification of Smoking-Associated Differentially Methylated Regions Using Reduced Representation Bisulfite Sequencing and Cell type-Specific Enhancer Activation and Gene Expression.Environmental health perspectives · 2018Article
- Hypermethylation ofOxidative medicine and cellular longevity · 2018Article
- DNA methylation in ELOVL2 and C1orf132 correctly predicted chronological age of individuals from three disease groups.International journal of legal medicine · 2018Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSeveral studies have reported age-associated changes in DNA methylation in the first few years of life and in adult populations, but the extent of such changes during childhood is less well studied. The goals of this study were to investigate to what degree intra-individual changes in DNA methylation are associated with aging during childhood and dissect the methylation changes directly associated with aging from the effect mediated through variation in cell-type composition (CTC).
resultsWe performed reduced representation bisulfite sequencing (RRBS) in peripheral whole-blood samples collected at 2, 10, and 16 years of age. We identified age-associated longitudinal changes in DNA methylation at 346 CpGs in 178 genes. Analyses separating the effect mediated by CTC variability across age identified 26 CpGs located in 12 genes that associated directly with age. Hence, the CTC changes across age appear to act as a mediator of the observed DNA methylation associated with age. The results were replicated using EpiTYPER in a second sample set selected from the same cohort. Gene ontology analyses revealed enrichment of transcriptional regulation and developmental processes. Further, comparisons of the mean DNA methylation differences between the time points reveal greater differences between 2 to 10 years and 10 to 16 years, suggesting that the identified age-associated DNA methylation patterns manifests in early childhood.
conclusionsThis study reveals insights into the epigenetic dynamics associated with aging early in life. Such information could ultimately provide clues and point towards molecular pathways that are susceptible to aging-related disease-associated epigenetic dysregulation.
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