Evidence map›Paper›PMID 27785017›Full record

ArticleInternational journal of nanomedicine

Recombinant epidermal growth factor-like domain-1 from coagulation factor VII functionalized iron oxide nanoparticles for targeted glioma magnetic resonance imaging.

Heng Liu, Xiao Chen, Wei Xue, Chengchao Chu, Yu Liu, Haipeng Tong, Xuesong Du, Tian Xie, Gang Liu, Weiguo Zhang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of nanomedicine. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Membrane heat shock protein 70: a theranostic target for cancer therapy.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2018
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Heng LiuDepartment of Radiology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing; State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, Fujian.
Xiao ChenDepartment of Radiology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing.
Wei XueDepartment of Radiology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing.
Chengchao ChuState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, Fujian.
Yu LiuState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, Fujian.
Haipeng TongDepartment of Radiology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing.
Xuesong DuDepartment of Radiology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing.
Tian XieDepartment of Radiology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing.
Gang LiuState Key Laboratory of Molecular Vaccinology and Molecular Diagnostics, Center for Molecular Imaging and Translational Medicine, School of Public Health, Xiamen University, Xiamen, Fujian.
Weiguo ZhangDepartment of Radiology, Institute of Surgery Research, Daping Hospital, Third Military Medical University, Chongqing; Chongqing Clinical Research Center for Imaging and Nuclear Medicine, Chongqing, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The highly infiltrative and invasive nature of glioma cells often leads to blurred tumor margins, resulting in incomplete tumor resection and tumor recurrence. Accurate detection and precise delineation of glioma help in preoperative delineation, surgical planning and survival prediction. In this study, recombinant epidermal growth factor-like domain-1, derived from human coagulation factor VII, was conjugated to iron oxide nanoparticles (IONPs) for targeted glioma magnetic resonance (MR) imaging. The synthesized EGF1-EGFP-IONPs exhibited excellent targeting ability toward tissue factor (TF)-positive U87MG cells and human umbilical vein endothelial cells in vitro, and demonstrated persistent and efficient MR contrast enhancement up to 12 h for preclinical glioma models with high targeting specificity in vivo. They hold great potential for clinical translation and developing targeted theranostics against brain glioma.

Indexed as

AnimalsCells, CulturedCell SurvivalFactor VIIGliomaHumansHuman Umbilical Vein Endothelial CellsImage Processing, Computer-AssistedMagnetic Resonance ImagingMagnetite NanoparticlesMiceMice, Inbred BALB CMice, NudeMitochondrial ProteinsPeptide Elongation Factor GFactor VIIGFM1 protein, humanMagnetite NanoparticlesMitochondrial ProteinsPeptide Elongation Factor Gepidermal growth factor-like domain-1gliomairon oxide nanoparticlesMRItissue factor

Identifiers

PMID27785017
PMCPMC5063593

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.