Evidence map›Paper›PMID 27784905›Full record

ReviewNature cell biology2016

A new bookmark of the mitotic genome in embryonic stem cells.

Chris C-S Hsiung, Gerd A Blobel

Abstract readReview
In one paragraph

Review in Nature cell biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Chris C-S HsiungDivision of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.
Gerd A BlobelDivision of Hematology, The Children's Hospital of Philadelphia, Philadelphia, PA 19104, USA.

Funding

Transcriptional Networks Controlling Erythroid DifferentiationR01DK054937 · NIDDK · CHILDREN'S HOSP OF PHILADELPHIA · PI Gerd A Blobel · 1999 to 2026
$12.8M
PREDOCTORAL TRAINING PROGRAM IN GENETICST32GM008216 · NIGMS · UNIVERSITY OF PENNSYLVANIA · PI EPSTEIN, DOUGLAS J · 1987 to 2023
$8.3M
NIDDK NIH HHS R01 DK054937NIGMS NIH HHS T32 GM008216
6 · The paper itself

Abstract

Embryonic stem cells maintain pluripotency through countless mitoses. A recent report shows that the transcription factor Esrrb remains bound to chromatin during mitosis, including at regulatory regions that support pluripotency. Mitotic chromatin occupancy by Esrrb might stabilize the defining transcriptional programmes of embryonic stem cells through cell division.

Indexed as

Gene Expression Regulation, DevelopmentalAnimalsChromatinEmbryonic Stem CellsGenomeHumansMitosisProtein BindingTranscription FactorsChromatinTranscription Factors

Identifiers

PMID27784905
PMCPMC5742480

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.