ReviewMicrobiology and molecular biology reviews : MMBR2016
YopJ Family Effectors Promote Bacterial Infection through a Unique Acetyltransferase Activity.
Review in Microbiology and molecular biology reviews : MMBR, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
53 citing papers in PubMed.
- Pathogenicity and virulence ofVirulence · 2026Review
- Insights Into the Role of Lysine Acetylation of Non-Histone Proteins in Plant Immunity.Plant, cell & environment · 2026Review
- ThebioRxiv : the preprint server for biology · 2026Article
- Ralstonia solanacearum Acetyltransferase RipU Hijacks SlJAR1 to Inhibit Jasmonic Acid Signalling and Facilitate Pathogen Infection.Plant biotechnology journal · 2026Article
- Reprogramming of bacterial virulence by lysine acetylation.Nature communications · 2026Article
- XopA: a novel type III secretion system effector inMicrobiology spectrum · 2026Article
- Bioorthogonal Click Chemistry for Antibody-Free Profiling of Acetylation, Propionylation, and Butyrylation inACS infectious diseases · 2026Article
- A bacterial YopJ-family acetyltransferase suppresses host immune response by Nε-acetylation of JAK1.Nature communications · 2026Article
- The Recognition of YopJ Family Effectors Depends on ZAR1/JIM2 Immune Complex in Nicotiana benthamiana.Molecular plant pathology · 2026Article
- CanineMicrobial genomics · 2026Article
- Three ARID proteins involved in chromatin remodeling PEAT complexes are targeted by the Ralstonia solanacearum effector PopP2 and contribute to bacterial wilt disease.The Plant journal : for cell and molecular biology · 2025Article
- Molecular Dialog ofInternational journal of molecular sciences · 2025Review
- Lysine acetylation in cyanobacteria: emerging mechanisms and functions.Biochemical Society transactions · 2025Review
- Comparative pan-genomic analysis reveals pathogenic mechanisms and genomic plasticity inFrontiers in cellular and infection microbiology · 2025Article
- Pathogenicity and virulence ofVirulence · 2024Review
- Acetylated bacterial proteins as potent antigens inducing an anti-modified protein antibody response.RMD open · 2024Article
- Translocation of YopJ family effector proteins through the VirB/VirD4 T4SS ofProceedings of the National Academy of Sciences of the United States of America · 2024Article
- The Molecular Genetics and Genomics of Plant-Pathogen Interactions.International journal of molecular sciences · 2024Article
- Bacterial host adaptation through sequence and structural variations of a single type III effector gene.iScience · 2024Article
- Comparative genomic analysis uncovered phylogenetic diversity, evolution of virulence factors, and horizontal gene transfer events in tomato bacterial spotFrontiers in microbiology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Gram-negative bacterial pathogens rely on the type III secretion system to inject virulence proteins into host cells. These type III secreted "effector" proteins directly manipulate cellular processes to cause disease. Although the effector repertoires in different bacterial species are highly variable, the Yersinia outer protein J (YopJ) effector family is unique in that its members are produced by diverse animal and plant pathogens as well as a nonpathogenic microsymbiont. All YopJ family effectors share a conserved catalytic triad that is identical to that of the C55 family of cysteine proteases. However, an accumulating body of evidence demonstrates that many YopJ effectors modify their target proteins in hosts by acetylating specific serine, threonine, and/or lysine residues. This unique acetyltransferase activity allows the YopJ family effectors to affect the function and/or stability of their targets, thereby dampening innate immunity. Here, we summarize the current understanding of this prevalent and evolutionarily conserved type III effector family by describing their enzymatic activities and virulence functions in animals and plants. In particular, the molecular mechanisms by which representative YopJ family effectors subvert host immunity through posttranslational modification of their target proteins are discussed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.