ArticleOpen biology2016
Coordinated regulation of the ESCRT-III component CHMP4C by the chromosomal passenger complex and centralspindlin during cytokinesis.
Article in Open biology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 42 citations in OpenAlex.
- ESCRT-III assembles around mis-segregated DNA to protect genome stability.Nature structural & molecular biology · 2026Article
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- Mapping Small Extracellular Vesicle Secretion Potential in Healthy Human Gingiva Using Spatial Transcriptomics.Current issues in molecular biology · 2025Article
- Identification of hub biomarkers and immune cell infiltrations participating in the pathogenesis of endometriosis.Scientific reports · 2025Article
- Article
- Caveolae promote successful abscission by controlling intercellular bridge tension during cytokinesis.Science advances · 2022Article
- Mechanics and regulation of cytokinetic abscission.Frontiers in cell and developmental biology · 2022Review
- Anillin/Mid1p interacts with the ESCRT-associated protein Vps4p and mitotic kinases to regulate cytokinesis in fission yeast.Cell cycle (Georgetown, Tex.) · 2021Article
- Article
- Article
- A cancer-associated, genome protective programme engaging PKCε.Advances in biological regulation · 2020Review
- Chromatin modified protein 4C (CHMP4C) facilitates the malignant development of cervical cancer cells.FEBS open bio · 2020Article
- Article
- Actin reduction by MsrB2 is a key component of the cytokinetic abscission checkpoint and prevents tetraploidy.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- The many functions of ESCRTs.Nature reviews. Molecular cell biology · 2020Review
- CDK11The Journal of biological chemistry · 2019Article
- Transcriptional Activation of Arabidopsis Zygotes Is Required for Initial Cell Divisions.Scientific reports · 2019Article
- Cell cycle-independent furrowing triggered by phosphomimetic mutations of the INCENP STD motif requires Plk1.Journal of cell science · 2019Article
- Building bridges between chromosomes: novel insights into the abscission checkpoint.Cellular and molecular life sciences : CMLS · 2019Review
- The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis.Nature communications · 2019Article
Corrections and comments
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
The chromosomal passenger complex (CPC)-composed of Aurora B kinase, Borealin, Survivin and INCENP-surveys the fidelity of genome segregation throughout cell division. The CPC has been proposed to prevent polyploidy by controlling the final separation (known as abscission) of the two daughter cells via regulation of the ESCRT-III CHMP4C component. The molecular details are, however, still unclear. Using atomic force microscopy, we show that CHMP4C binds to and remodels membranes in vitro Borealin prevents the association of CHMP4C with membranes, whereas Aurora B interferes with CHMP4C's membrane remodelling activity. Moreover, we show that CHMP4C phosphorylation is not required for its assembly into spiral filaments at the abscission site and that two distinctly localized pools of phosphorylated CHMP4C exist during cytokinesis. We also characterized the CHMP4C interactome in telophase cells and show that the centralspindlin complex associates preferentially with unphosphorylated CHMP4C in cytokinesis. Our findings indicate that gradual dephosphorylation of CHMP4C triggers a 'relay' mechanism between the CPC and centralspindlin that regulates the timely distribution and activation of CHMP4C for the execution of abscission.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.