Evidence map›Paper›PMID 27784692›Full record

ArticleAmerican journal of physiology. Renal physiology2017

A kidney-selective biopolymer for targeted drug delivery.

Gene L Bidwell, Fakhri Mahdi, Qingmei Shao, Omar C Logue, Jamarius P Waller, Caleb Reese, Alejandro R Chade

Open access · bronzeAbstract read
In one paragraph

Article in American journal of physiology. Renal physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 42 papers.

0numbers the graph read from it
0cells of the map it votes in
42citing papers in PubMed
3.1field-weighted citation impact, top 8% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

42 citing papers in PubMed, 71 citations in OpenAlex.

  1. Review
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  6. Nanotherapeutics in Kidney Disease: Innovations, Challenges, and Future Directions.Journal of the American Society of Nephrology : JASN · 2025
    Review
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  8. Article
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  14. Novel Drug Delivery Technologies and Targets for Renal Disease.Hypertension (Dallas, Tex. : 1979) · 2022
    Review
  15. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 1 country.

Gene L BidwellDepartment of Neurology, University of Mississippi Medical Center, Jackson, Mississippi; gbidwell@umc.edu.ORCID 0000-0001-9104-150X
Fakhri MahdiDepartment of Neurology, University of Mississippi Medical Center, Jackson, Mississippi.
Qingmei ShaoDepartment of Neurology, University of Mississippi Medical Center, Jackson, Mississippi.
Omar C LogueDepartment of Neurology, University of Mississippi Medical Center, Jackson, Mississippi.
Jamarius P WallerDepartment of Neurology, University of Mississippi Medical Center, Jackson, Mississippi.
Caleb ReeseBelhaven University, Jackson, Mississippi; and.
Alejandro R ChadeDepartments of Physiology and Biophysics, Medicine, and Radiology, University of Mississippi Medical Center, Jackson, Mississippi.
University of Mississippi Medical Center · USBelhaven University · USJackson Memorial Hospital · US

Funding

A Novel Protein Delivery System for Therapy of PreeclampsiaR01HL121527 · NHLBI · UNIVERSITY OF MISSISSIPPI MED CTR · PI BIDWELL, GENE LEFLORE · 2014 to 2023
$4.1M
Microcirculation in Renovascular HypertensionR01HL095638 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI CHADE, ALEJANDRO ROBERTO · 2010 to 2021
$3.9M
NHLBI NIH HHS R01 HL095638NHLBI NIH HHS R01 HL121527
6 · The paper itself

Abstract

Improving drug delivery to the kidney using renal-targeted therapeutics is a promising but underdeveloped area. We aimed to develop a kidney-targeting construct for renal-specific drug delivery. Elastin-like polypeptides (ELPs) are nonimmunogenic protein-based carriers that can stabilize attached small-molecule and peptide therapeutics. We modified ELP at its NH

Indexed as

Drug Delivery SystemsAnimalsBiopolymersElastinHalf-LifeKidneyPeptidesProteinsRats, Sprague-DawleySwineTissue DistributionBiopolymersElastinendozepine-like peptide ELPPeptidesProteinsbiopolymerdrug deliveryelastin-like polypeptidekidney targeting peptiderenal disease

Identifiers

PMID27784692
PMCPMC5283886
OpenAlexW2545215204

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.