ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2016
Central vs. peripheral determinants of sympathetic neural recruitment: insights from static handgrip exercise and postexercise circulatory occlusion.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed.
- Innovative Dose-Response Assessment of the Metaboreflex With Indirect Control of Intramuscular Metabolic Perturbation in Humans.Acta physiologica (Oxford, England) · 2026Trial
- Prognostic value of exercise blood pressure: role of fitness and exercise training.American journal of physiology. Heart and circulatory physiology · 2026Review
- Central αThe Journal of physiology · 2024Article
- Blood pressure responses to handgrip exercise but not apnea or mental stress are enhanced in women with a recent history of preeclampsia.American journal of physiology. Heart and circulatory physiology · 2024Article
- A century of exercise physiology: key concepts in neural control of the circulation.European journal of applied physiology · 2024Review
- Autonomic cardiovascular control during exercise.American journal of physiology. Heart and circulatory physiology · 2023Review
- Blood pressure regulation during exercise: is age central to the problem?The Journal of physiology · 2023Article
- Impaired sympathetic neural recruitment during exercise pressor reflex activation in women with post-traumatic stress disorder.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2022Article
- The impact of ageing and sex on sympathetic neurocirculatory regulation.Seminars in cell & developmental biology · 2021Review
- Central Command and the Regulation of Exercise Heart Rate Response in Heart Failure With Preserved Ejection Fraction.Circulation · 2021Article
- Muscle sympathetic single-unit response patterns during progressive muscle metaboreflex activation in young healthy adults.Journal of neurophysiology · 2020Article
- Sympathetic neural recruitment strategies following acute intermittent hypoxia in humans.American journal of physiology. Regulatory, integrative and comparative physiology · 2020Article
- Sex Differences in the Sympathetic Neural Recruitment and Hemodynamic Response to Head-Up Tilt in Older Hypertensives.Hypertension (Dallas, Tex. : 1979) · 2020Article
- Asynchronous action potential discharge in human muscle sympathetic nerve activity.American journal of physiology. Heart and circulatory physiology · 2019Article
- The role of the paravertebral ganglia in human sympathetic neural discharge patterns.The Journal of physiology · 2018Article
- Sex differences in diaphragmatic fatigue: the cardiovascular response to inspiratory resistance.The Journal of physiology · 2018Article
- Pharmacological assessment of the contribution of the arterial baroreflex to sympathetic discharge patterns in healthy humans.Journal of neurophysiology · 2018Article
- Fifty years of microneurography: learning the language of the peripheral sympathetic nervous system in humans.Journal of neurophysiology · 2018Review
- Long-duration bed rest modifies sympathetic neural recruitment strategies in male and female participants.Journal of applied physiology (Bethesda, Md. : 1985) · 2018Article
- Recruitment strategies in efferent sympathetic nerve activity.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Sympathetic outflow is modified during acute homeostatic stress through increased firing of low-threshold axons, recruitment of latent axons, and synaptic delay modifications. However, the role of central mechanisms versus peripheral reflex control over sympathetic recruitment remains unknown. Here, we examined sympathetic discharge patterns during fatiguing static handgrip (SHG) exercise and postexercise circulatory occlusion (PECO) to study the central vs. peripheral reflex elements of sympathetic neural coding. Muscle sympathetic nerve activity (MSNA; microneurography) was measured in six males (25 ± 3 yr) at baseline (3 min) and during 5 min of SHG exercise completed at 20% maximal voluntary contraction. Isolation of the peripheral metaboreflex component was achieved by PECO for 3 min. Action potential (AP) patterns were studied using wavelet-based methodology. Compared with baseline, total MSNA increased by minute 3 of SHG, remaining elevated throughout the duration of exercise and PECO (all P < 0.05). The AP content per burst increased above baseline by minute 4 of SHG (Δ4 ± 2), remaining elevated at minute 5 (Δ6 ± 4) and PECO (Δ4 ± 4; all P < 0.05). Similarly, total AP clusters increased by minute 4 of SHG (Δ5 ± 5) and remained elevated at minute 5 (Δ6 ± 3) and PECO (Δ7 ± 5; all P < 0.01), indicating recruitment of latent subpopulations. Finally, the AP cluster size-latency profile was shifted downward during minutes 4 (-32 ± 22 ms) and 5 (-49 ± 17 ms; both P < 0.05) of SHG but was not different than baseline during PECO (P > 0.05). Our findings suggest that central perceptual factors play a specific role in the synaptic delay aspect of sympathetic discharge timing, whereas peripheral reflex mechanisms affect recruitment of latent axons.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.