ArticleAmerican journal of physiology. Regulatory, integrative and comparative physiology2017
High-intensity interval training, but not continuous training, reverses right ventricular hypertrophy and dysfunction in a rat model of pulmonary hypertension.
Article in American journal of physiology. Regulatory, integrative and comparative physiology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 2 of them syntheses that pooled it.
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Who cites it
40 citing papers in PubMed, 2 syntheses or guidelines pooled it, 77 citations in OpenAlex.
- Training programs in preclinical studies. The example of pulmonary hypertension. Systematic review and meta-analysis.PloS one · 2022Pooled it
- A Handful of Details to Ensure the Experimental Reproducibility on the FORCED Running Wheel in Rodents: A Systematic Review.Frontiers in endocrinology · 2021Pooled it
- Pulmonary vascular response to high-intensity interval training in deployment-related respiratory disease: a pilot clinical trial.Annals of the American Thoracic Society · 2026Article
- Skeletal muscle atrophy in pulmonary arterial hypertension: potential mechanisms and effects of physical exercise.Heart failure reviews · 2025Review
- Impact of combined exercise training in peripheral and diaphragm muscles and in mortality in a preclinical model of pulmonary arterial hypertension.Pflugers Archiv : European journal of physiology · 2025Article
- Potential Mechanisms of Exercise-Mediated Ferroptosis Regulation in Central Nervous System Diseases.Molecular neurobiology · 2025Review
- Article
- Bulk and regional diaphragm blood flow during chemical hyperpnea in pulmonary hypertensive rats.Respiratory physiology & neurobiology · 2025Article
- Skeletal and respiratory muscle blood flow redistribution during submaximal exercise in pulmonary hypertensive rats.The Journal of physiology · 2025Article
- Relationship between physical exercise and COVID-19 (SARS-CoV-2): systematic review.Sport sciences for health · 2023Review
- Pulmonary hypertension alters blood flow distribution and impairs the hyperemic response in the rat diaphragm.Frontiers in physiology · 2023Article
- Moderate intensity continuous versus high intensity interval training: Metabolic responses of slow and fast skeletal muscles in rat.PloS one · 2023Article
- Skeletal muscle dysfunctions in pulmonary arterial hypertension: Effects of aerobic exercise training.Frontiers in physiology · 2023Review
- Pulmonary Hypertension Association's 2022 International Conference Scientific Sessions Overview.Pulmonary circulation · 2023Article
- Skeletal muscle blood flow during exercise is reduced in a rat model of pulmonary hypertension.American journal of physiology. Regulatory, integrative and comparative physiology · 2022Article
- Cardioprotective Effect of Resistance Exercise on Left Ventricular Remodeling Associated with Monocrotaline-Induced Pulmonary Arterial Hypertension.Arquivos brasileiros de cardiologia · 2022Article
- Effects of pulmonary hypertension on microcirculatory hemodynamics in rat skeletal muscle.Microvascular research · 2022Article
- Acute and chronic exercise training in patients with Class II pulmonary hypertension: effects on haemodynamics and symptoms.ESC heart failure · 2022Review
- Modulation of soluble guanylate cyclase ameliorates pulmonary hypertension in a rat model of chronic thromboembolic pulmonary hypertension by stimulating angiogenesis.Physiological reports · 2022Article
- Activation of TRPV4 by lactate as a critical mediator of renal fibrosis in spontaneously hypertensive rats after moderate- and high-intensity exercise.Frontiers in physiology · 2022Article
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Authors and funding
12 authors at 3 institutions in 1 country.
Funding
Abstract
Exercise is beneficial in pulmonary arterial hypertension (PAH), although studies to date indicate little effect on the elevated pulmonary pressures or maladaptive right ventricle (RV) hypertrophy associated with the disease. For chronic left ventricle failure, high-intensity interval training (HIIT) promotes greater endothelial stimulation and superior benefit than customary continuous exercise training (CExT); however, HIIT has not been tested for PAH. Therefore, here we investigated acute and chronic responses to HIIT vs. CExT in a rat model of monocrotaline (MCT)-induced mild PAH. Six weeks of treadmill training (5 times/wk) were performed, as either 30 min HIIT or 60 min low-intensity CExT. To characterize acute hemodynamic responses to the two approaches, novel recordings of simultaneous pulmonary and systemic pressures during running were obtained at pre- and 2, 4, 6, and 8 wk post-MCT using long-term implantable telemetry. MCT-induced decrement in maximal aerobic capacity was ameliorated by both HIIT and CExT, with less pronounced pulmonary vascular remodeling and no increase in RV inflammation or apoptosis observed. Most importantly, only HIIT lowered RV systolic pressure, RV hypertrophy, and total pulmonary resistance, and prompted higher cardiac index that was complemented by a RV increase in the positive inotrope apelin and reduced fibrosis. HIIT prompted a markedly pulsatile pulmonary pressure during running and was associated with greater lung endothelial nitric oxide synthase after 6 wk. We conclude that HIIT may be superior to CExT for improving hemodynamics and maladaptive RV hypertrophy in PAH. HIIT's superior outcomes may be explained by more favorable pulmonary vascular endothelial adaptation to the pulsatile HIIT stimulus.
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