ReviewSchizophrenia research2017
Toward understanding thalamocortical dysfunction in schizophrenia through computational models of neural circuit dynamics.
Review in Schizophrenia research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
36 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Meta-analytic evidence for altered mesolimbic responses to reward in schizophrenia.Human brain mapping · 2018Pooled it
- Mechanistic corticostriatal circuit model predicts learning-dependent fMRI dynamics and individual reward bias in humans.bioRxiv : the preprint server for biology · 2026Article
- Aging in Schizophrenia: Perspectives on Molecular Mechanisms and a Mini-review.Schizophrenia bulletin · 2026Review
- The spatial extent of anatomical connections within the thalamus varies across the cortical hierarchy in humans and macaques.bioRxiv : the preprint server for biology · 2025Article
- Mediodorsal thalamus regulates task uncertainty to enable cognitive flexibility.Nature communications · 2025Article
- Auditory and Visual Thalamocortical Connectivity Alterations in Unmedicated People with Schizophrenia: An Individualized Sensory Thalamic Localization and Resting-State Functional Connectivity Study.medRxiv : the preprint server for health sciences · 2024Article
- Increasing the Construct Validity of Computational Phenotypes of Mental Illness Through Active Inference and Brain Imaging.Brain sciences · 2024Review
- A neural modeling approach to study mechanisms underlying the heterogeneity of visual spatial frequency sensitivity in schizophrenia.Schizophrenia (Heidelberg, Germany) · 2024Article
- Cognitive Control in Schizophrenia: Advances in Computational Approaches.Current directions in psychological science · 2024Article
- Functional Connectivity Biomarkers in Schizophrenia.Advances in neurobiology · 2024Review
- Functional localization of the human auditory and visual thalamus using a thalamic localizer functional magnetic resonance imaging task.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- GABAergic dysfunction in postmortem dorsolateral prefrontal cortex: implications for cognitive deficits in schizophrenia and affective disorders.Frontiers in cellular neuroscience · 2024Review
- Neurostructural changes in schizophrenia and treatment-resistance: a narrative review.Psychoradiology · 2024Review
- A neural modeling approach to study mechanisms underlying the heterogeneity of visual spatial frequency sensitivity in schizophrenia.bioRxiv : the preprint server for biology · 2023Article
- Dynamic functional thalamocortical dysconnectivity in schizophrenia correlates to antipsychotics response.Schizophrenia (Heidelberg, Germany) · 2023Article
- A neural model of modified excitation/inhibition and feedback levels in schizophrenia.bioRxiv : the preprint server for biology · 2023Article
- A neural model of modified excitation/inhibition and feedback levels in schizophrenia.Frontiers in psychiatry · 2023Article
- Cortico-thalamic development and disease: From cells, to circuits, to schizophrenia.Frontiers in neuroanatomy · 2023Review
- The thalamus in psychosis spectrum disorder.Frontiers in neuroscience · 2023Article
- Dorsolateral Prefrontal Cortex Glutamate/Gamma-Aminobutyric Acid (GABA) Alterations in Clinical High Risk and First-Episode Schizophrenia: A Preliminary 7-T Magnetic Resonance Spectroscopy Imaging Study.International journal of molecular sciences · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The thalamus is implicated in the neuropathology of schizophrenia, and multiple modalities of noninvasive neuroimaging provide converging evidence for altered thalamocortical dynamics in the disorder, such as functional connectivity and oscillatory power. However, it remains a challenge to link these neuroimaging biomarkers to underlying neural circuit mechanisms. One potential path forward is a "Computational Psychiatry" approach that leverages computational models of neural circuits to make predictions for the dynamical impact dynamical impact on specific thalamic disruptions hypothesized to occur in the pathophysiology of schizophrenia. Here we review biophysically-based computational models of neural circuit dynamics for large-scale resting-state networks which have been applied to schizophrenia, and for thalamic oscillations. As a key aspect of thalamocortical dysconnectivity in schizophrenia is its regional specificity, it is important to consider potential sources of intrinsic heterogeneity of cellular and circuit properties across cortical and thalamic structures.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.