Evidence map›Paper›PMID 27784529›Full record

ArticleEuro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin2016

Trivalent inactivated influenza vaccine effective against influenza A(H3N2) variant viruses in children during the 2014/15 season, Japan.

Norio Sugaya, Masayoshi Shinjoh, Chiharu Kawakami, Yoshio Yamaguchi, Makoto Yoshida, Hiroaki Baba, Mayumi Ishikawa, Mio Kono, Shinichiro Sekiguchi, Takahisa Kimiya and 14 more

Open access · diamondAbstract read
In one paragraph

Article in Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed, 1 pooled it
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Within and between classroom transmission patterns of seasonal influenza among primary school students in Matsumoto city, Japan.Proceedings of the National Academy of Sciences of the United States of America · 2021
    Article
  5. Article
  6. Article
  7. Effectiveness of trivalent inactivated influenza vaccines in children during 2017-2018 season in Korea: Comparison of test-negative analysis by rapid and RT-PCR influenza tests.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020
    Article
  8. Article
  9. Article
  10. Genetic and antigenic characterisation of influenza A(H3N2) viruses isolated in Yokohama during the 2016/17 and 2017/18 influenza seasons.Euro surveillance : bulletin Europeen sur les maladies transmissibles = European communicable disease bulletin · 2019
    Article
  11. Review
  12. Article
  13. Clinical characteristics of influenza virus-induced lower respiratory infection during the 2015 to 2016 season.Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy · 2018
    Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors at 19 institutions in 1 country.

Norio SugayaKeiyu Hospital, Yokohama, Kanagawa, Japan.
Masayoshi Shinjoh
Chiharu Kawakami
Yoshio Yamaguchi
Makoto Yoshida
Hiroaki Baba
Mayumi Ishikawa
Mio Kono
Shinichiro Sekiguchi
Takahisa Kimiya
Keiko Mitamura
Motoko Fujino
Osamu Komiyama
Naoko Yoshida
Kenichiro Tsunematsu
Atsushi Narabayashi
Yuji Nakata
Akihiro Sato
Nobuhiko Taguchi
Hisayo Fujita
Machiko Toki
Michiko Myokai
Ichiro Ookawara
Takao Takahashi
Keio University · JPkeiyu Hospital · JPNational Hospital Organization · JPEiju General Hospital · JPFuji Heavy Industries Health Insurance Society Ota Memorial Hospital · JPHiratsuka City Hospital · JPHiratsuka Kyosai Hospital · JPKanagawa Prefectural Institute of Public Health · JPKawasaki Municipal Hospital · JPNagano Municipal Hospital · JPSaiseikai Central Hospital · JPSaitama Municipal Hospital · JPSendai Kousei Hospital · JPShizuoka City Shimizu Hospital · JPShizuoka Red Cross Hospital · JPTachikawa Hospital · JPTochigi Medical Center · JPTokyo Metropolitan Ohtsuka Hospital · JPYokohama Municipal Citizen's Hospital · JP

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The 2014/15 influenza season in Japan was characterised by predominant influenza A(H3N2) activity; 99% of influenza A viruses detected were A(H3N2). Subclade 3C.2a viruses were the major epidemic A(H3N2) viruses, and were genetically distinct from A/New York/39/2012(H3N2) of 2014/15 vaccine strain in Japan, which was classified as clade 3C.1. We assessed vaccine effectiveness (VE) of inactivated influenza vaccine (IIV) in children aged 6 months to 15 years by test-negative case-control design based on influenza rapid diagnostic test. Between November 2014 and March 2015, a total of 3,752 children were enrolled: 1,633 tested positive for influenza A and 42 for influenza B, and 2,077 tested negative. Adjusted VE was 38% (95% confidence intervals (CI): 28 to 46) against influenza virus infection overall, 37% (95% CI: 27 to 45) against influenza A, and 47% (95% CI: -2 to 73) against influenza B. However, IIV was not statistically significantly effective against influenza A in infants aged 6 to 11 months or adolescents aged 13 to 15 years. VE in preventing hospitalisation for influenza A infection was 55% (95% CI: 42 to 64). Trivalent IIV that included A/New York/39/2012(H3N2) was effective against drifted influenza A(H3N2) virus, although vaccine mismatch resulted in low VE.

Indexed as

Vaccines, InactivatedAdolescentAntigens, ViralChildChild, PreschoolFemaleHumansInfantInfluenza A Virus, H3N2 SubtypeInfluenza, HumanInfluenza VaccinesJapanMalePopulation SurveillanceRespiratory Tract InfectionsSeasonsAntigens, ViralInfluenza VaccinesVaccines, InactivatedInfluenzaInfluenza VirusLaboratory surveillancevaccine and immunizationvaccine effectiveness

Identifiers

PMID27784529
PMCPMC5291153
OpenAlexW2542990401

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.