Evidence map›Paper›PMID 27784508›Full record

ReviewInternational journal of circumpolar health2016

Erythema nodosum and the risk of tuberculosis in a high incidence setting.

Karen Bjorn-Mortensen, Karin Ladefoged, Jacob Simonsen, Sascha W Michelsen, Hans Christian F Sørensen, Anders Koch, Troels Lillebaek, Aase Bengaard Andersen, Bolette Soborg

Open access · goldAbstract readReview
In one paragraph

Review in International journal of circumpolar health, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
2.0field-weighted citation impact, top 13% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Erythema Nodosum: A Practical Approach and Diagnostic Algorithm.American journal of clinical dermatology · 2021
    Review
  2. Article
  3. Skin manifestations in spondyloarthritis.Therapeutic advances in musculoskeletal disease · 2020
    Review
  4. Erythema nodosum.World journal of pediatrics : WJP · 2018
    Review
  5. Erythema nodosum as sign of primary tuberculosis.Oxford medical case reports · 2017
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 2 countries.

Karen Bjorn-MortensenDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Karin LadefogedDepartment of Internal Medicine, Queen Ingrid's Hospital, Nuuk, Greenland.
Jacob SimonsenDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Sascha W MichelsenDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Hans Christian F SørensenTasiilaq Hospital, Tasiilaq, Greenland.
Anders KochDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Troels LillebaekInternational Reference Laboratory of Mycobacteriology, Statens Serum Institut, Copenhagen, Denmark.
Aase Bengaard AndersenInstitute of Clinical Medicine, University of Southern Denmark, Odense, Denmark.
Bolette SoborgDepartment of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark.
Statens Serum Institut · DKCopenhagen University Hospital · DKQueen Ingrid's Hospital · GLUniversity of Southern Denmark · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study estimates the erythema nodosum (EN) incidence in a tuberculosis (TB) endemic setting and evaluates the likelihood of a subsequent TB diagnosis among individuals with

designWe estimated EN incidence rates (IRs) in East Greenland in 2010-2011 and conducted a cohort study following all individuals who tested positive for MTI from 1 January 2010 until 31 December 2012. A personal identifier allowed individual follow-up in the mandatory TB register. MTI was defined by a positive interferon-gamma release assay. TB incidence rate ratios (IRRs) among participants with or without EN were estimated with the Cox proportional hazard model.

resultsWe identified 38 EN cases corresponding to an IR of 500/100,000 inhabitants/year. All cases were among individuals with MTI. The EN IR was 11.79 (95% CI 5.73-24.27) times higher for BCG-unvaccinated compared with BCG-vaccinated individuals. The TB IRR was 25 (95% CI 11-60) within 1 month of EN compared to individuals without EN.

conclusionThis study documents a high EN incidence in a TB endemic region. EN occurred only in individuals with MTI, and predominantly among BCG-unvaccinated individuals. EN was significantly associated with a TB diagnosis within 1 month of diagnosis.

Indexed as

AdultBCG VaccineCausalityCohort StudiesErythema NodosumFemaleGreenlandHumansIncidenceInterferon-gamma Release TestsMaleMycobacterium tuberculosisRisk FactorsTuberculosisTuberculosis, PulmonaryYoung AdultBCG VaccineErythema NodosumGreenlandinterferon gamma release assaymycobacterium tuberculosisTuberculosis

Identifiers

PMID27784508
PMCPMC5081485
OpenAlexW2534330787

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.