ArticleHippocampus2017
Dendrites of dentate gyrus granule cells contribute to pattern separation by controlling sparsity.
Article in Hippocampus, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- An Update on the Model of Connectivity of the Hippocampal Formation (I): The Perforant Pathway to the Dentate Gyrus.Hippocampus · 2026Article
- Sparsity and memory constraints interact with training sequence to bias learning of associative maps.Neuropsychologia · 2026Article
- Synaptic plasticity in the perforant pathway drives inhibitory reorganization enhancing dentate gyrus functionality.iScience · 2026Article
- Intersection of transient cell states with stable cell types in hippocampus.bioRxiv : the preprint server for biology · 2025Article
- A compressed code for memory discrimination.bioRxiv : the preprint server for biology · 2025Article
- The effects of bipolar disorder granule cell hyperexcitability and lithium therapy on pattern separation in a computational model of the dentate gyrus.Translational psychiatry · 2025Article
- Degeneracy Explains Diversity in Interneuronal Regulation of Pattern Separation in Heterogeneous Dentate Gyrus Networks.Function (Oxford, England) · 2025Article
- Selective inhibition in CA3: A mechanism for stable pattern completion through heterosynaptic plasticity.PLoS computational biology · 2025Article
- Mapping vascular network architecture in primate brain using ferumoxytol-weighted laminar MRI.eLife · 2025Article
- Effect of adult hippocampal neurogenesis on pattern separation and its applications.Cognitive neurodynamics · 2024Article
- Adult neurogenesis in the hippocampal dentate gyrus affects sparsely synchronized rhythms, associated with pattern separation and integration.Cognitive neurodynamics · 2024Article
- An Information-Geometric Formulation of Pattern Separation and Evaluation of Existing Indices.Entropy (Basel, Switzerland) · 2024Article
- Effect of adult-born immature granule cells on pattern separation in the hippocampal dentate gyrus.Cognitive neurodynamics · 2024Article
- Robust and consistent measures of pattern separation based on information theory and demonstrated in the dentate gyrus.PLoS computational biology · 2024Article
- Introducing the Dendrify framework for incorporating dendrites to spiking neural networks.Nature communications · 2023Article
- Disynaptic effect of hilar cells on pattern separation in a spiking neural network of hippocampal dentate gyrus.Cognitive neurodynamics · 2022Article
- Ultrafast simulation of large-scale neocortical microcircuitry with biophysically realistic neurons.eLife · 2022Article
- Augmenting neurogenesis rescues memory impairments in Alzheimer's disease by restoring the memory-storing neurons.The Journal of experimental medicine · 2022Article
- Population and individual firing behaviors in sparsely synchronized rhythms in the hippocampal dentate gyrus.Cognitive neurodynamics · 2022Article
- Recurrent Excitatory Feedback From Mossy Cells Enhances Sparsity and Pattern Separation in the Dentate GyrusFrontiers in computational neuroscience · 2022Article
Corrections and comments
- Erratum issued
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The hippocampus plays a key role in pattern separation, the process of transforming similar incoming information to highly dissimilar, nonverlapping representations. Sparse firing granule cells (GCs) in the dentate gyrus (DG) have been proposed to undertake this computation, but little is known about which of their properties influence pattern separation. Dendritic atrophy has been reported in diseases associated with pattern separation deficits, suggesting a possible role for dendrites in this phenomenon. To investigate whether and how the dendrites of GCs contribute to pattern separation, we build a simplified, biologically relevant, computational model of the DG. Our model suggests that the presence of GC dendrites is associated with high pattern separation efficiency while their atrophy leads to increased excitability and performance impairments. These impairments can be rescued by restoring GC sparsity to control levels through various manipulations. We predict that dendrites contribute to pattern separation as a mechanism for controlling sparsity. © 2016 The Authors Hippocampus Published by Wiley Periodicals, Inc.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.