Evidence map›Paper›PMID 27783998›Full record

ArticleOncotarget2017

Hepatocellular carcinoma and antidepressants: a nationwide population-based study.

Vincent Chin-Hung Chen, Chiao-Fan Lin, Yi-Hsuan Hsieh, Hsin-Yi Liang, Kuo-You Huang, Wei-Che Chiu, Yena Lee, Roger S McIntyre, Hsiang-Lin Chan

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Oncotarget, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 1 synthesis or guideline pooled it, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 2 countries.

Vincent Chin-Hung ChenDepartment of Psychiatry, Chiayi Chang Gung Memorial Hospital, Chiayi, Taiwan.
Chiao-Fan LinDepartment of Psychiatry, Chang Gung University, Taoyuan, Taiwan.
Yi-Hsuan HsiehDepartment of Psychiatry, Chang Gung University, Taoyuan, Taiwan.
Hsin-Yi LiangDepartment of Psychiatry, Chang Gung University, Taoyuan, Taiwan.
Kuo-You HuangDepartment of Speech, Language Pathology and Audiology, Chung Shan Medical University, Taichung, Taiwan.
Wei-Che ChiuDepartment of Psychiatry, Cathay General Hospital, Taipei, Taiwan.
Yena LeeMood Disorders Psychopharmacology Unit, University Health Network, University of Toronto, Toronto, ON, USA.
Roger S McIntyreMood Disorders Psychopharmacology Unit, University Health Network, University of Toronto, Toronto, ON, USA.
Hsiang-Lin ChanDepartment of Psychiatry, Chang Gung University, Taoyuan, Taiwan.
Chang Gung University · TWHealth Net · USCathay General Hospital · TWChiayi Chang Gung Memorial Hospital · TWChung Shan Medical University · TWLinkou Chang Gung Memorial Hospital · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Hepatocellular carcinoma (HCC) is highly prevalent in Asia. Antidepressants have been associated with increase in hepatocellular carcinoma. This is the first Asian population-based study to evaluate the association between antidepressant use and risk of HCC. Based on Taiwan's National Health Insurance Research Database, we conducted a nationwide population-based study. A total of 49,998 cases with HCC were identified and paired with 244,236 randomly selected controls. The data was analyzed via the conditional logistic regression model adjusting for several confounding factors. Use of tricyclic antidepressants (TCAs) and selective serotonin reuptake inhibitors (SSRIs) was associated with lower risk for HCC. No apparent association was found between use of other classes of antidepressants and HCC, including monoamine oxidase inhibitors (MAOIs), serotonin norepinephrine reuptake inhibitors (SNRIs), trazodone, mirtazapine and bupropion. The findings of a protective effect of TCAs and SSRIs for HCC should be interpreted with caution and warrants further research.

Indexed as

AdultAgedAged, 80 and overAntidepressive AgentsCarcinoma, HepatocellularCase-Control StudiesHumansLiver NeoplasmsMiddle AgedOdds RatioPopulation SurveillanceSocioeconomic FactorsTaiwanYoung AdultAntidepressive Agentsantidepressantshepatocellular carcinomaTaiwan national insurance

Identifiers

PMID27783998
PMCPMC5444756
OpenAlexW2536692371

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.