ArticleThe Science of the total environment2017
Proximity to major roadways and prospectively-measured time-to-pregnancy and infertility.
Article in The Science of the total environment, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.
- Indoor and outdoor air pollution and couple fecundability: a systematic review.Human reproduction update · 2023Pooled it
- Dynamic associations between ambient air pollution and transitions of biochemical pregnancy, clinical pregnancy, and live birth among women treated with IVF/ICSI.Journal of assisted reproduction and genetics · 2026Article
- Residential Exposure to PMPaediatric and perinatal epidemiology · 2025Article
- Impact of Climate Change on Reproductive Health and Pregnancy Outcomes: A Systematic Review.Cureus · 2024Review
- Article
- Ambient traffic related air pollution in relation to ovarian reserve and oocyte quality in young, healthy oocyte donors.Environment international · 2024Article
- Air pollution and fecundability in a North American preconception cohort study.Environment international · 2023Article
- Association between traffic-related air pollution exposure and fertility-assisted births.Environmental research, health : ERH · 2023Article
- Ambient air pollution exposure assessments in fertility studies: A systematic review and guide for reproductive epidemiologists.Current epidemiology reports · 2022Article
- Anti-Müllerian Hormone Levels among Female Firefighters.International journal of environmental research and public health · 2022Article
- The effect of short term exposure to outdoor air pollution on fertility.Reproductive biology and endocrinology : RB&E · 2021Article
- Residential proximity to major roads and fecundability in a preconception cohort.Environmental epidemiology (Philadelphia, Pa.) · 2020Article
- Supplemental Folate and the Relationship Between Traffic-Related Air Pollution and Livebirth Among Women Undergoing Assisted Reproduction.American journal of epidemiology · 2019Article
- Time-Varying Exposure to Air Pollution and Outcomes of in Vitro Fertilization among Couples from a Fertility Clinic.Environmental health perspectives · 2019Article
- Residential proximity to major roadways and traffic in relation to outcomes of in vitro fertilization.Environment international · 2018Article
- Increase in fertility following coal and oil power plant retirements in California.Environmental health : a global access science source · 2018Article
- Time-varying cycle average and daily variation in ambient air pollution and fecundability.Human reproduction (Oxford, England) · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors at 4 institutions in 1 country.
Funding
Abstract
We aimed to study the potential impact of proximity to major roadways on time-to-pregnancy and infertility in couples attempting pregnancy in the Longitudinal Investigation of Fertility and Environment (LIFE) study (2005-2009), a population-based, prospective cohort study. Couples attempting pregnancy (n=500) were enrolled and followed prospectively until pregnancy or 12months of trying and 393 couples (78%) had complete data and full follow-up. Time-to-pregnancy was based on a standard protocol using fertility monitors, tracking estrone-3-glucuonide and luteinizing hormone, and pregnancy test kits to detect human chorionic gonadotropin (hCG). The fecundability odds ratio (FOR) and 95% confidence interval (CI) were estimated using proportional odds models. Infertility was defined as 12months of trying to conceive without an hCG pregnancy and the relative risk (RR) and 95% CI were estimated with log-binomial regression. Final models were adjusted for age, parity, study site, and salivary alpha-amylase, a stress marker. Infertile couples (53/393; 14%) tended to live closer to major roadways on average than fertile couples (689m vs. 843m, respectively) but the difference was not statistically significant. The likelihood of pregnancy was increased 3% for every 200m further away the couples residence was from a major roadway (FOR=1.03; CI=1.01-1.06). Infertility also appeared elevated at moderate distances compared to 1000m or greater, but estimates lacked precision. Our findings suggest that proximity to major roadways may be related to reductions in fecundity. Prospective data from larger populations is warranted to corroborate these findings.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.