Evidence map›Paper›PMID 27783851›Full record

SynthesisJournal of clinical periodontology2017

Regenerative potential of leucocyte- and platelet-rich fibrin. Part A: intra-bony defects, furcation defects and periodontal plastic surgery. A systematic review and meta-analysis.

Ana B Castro, Nastaran Meschi, Andy Temmerman, Nelson Pinto, Paul Lambrechts, Wim Teughels, Marc Quirynen

4 registry-linked trialsOpen access · bronzeAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Journal of clinical periodontology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 4 registered trials, which are not on this map. Cited by 115 papers, 19 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
115citing papers in PubMed, 19 pooled it
23.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03900013 naunknown statusnot on this mapstarted 2019, after this paper: background citation

Clinical and Radiographic Evaluation of Injectable PRF With Demineralized Freeze-Dried Bone Allograft (DFDBA) Compared to (DFDBA) in Treatment of Intraosseous Defects in Patients With Stage III Periodontitis: A Randomized Clinical Trial

TypeinterventionalSponsorCairo UniversityRan2019 to 2021Enrolled20ConditionsIntrabony Periodontal DefectArmsInjectable platelet rich fibrin combined with DFDBA, Demineralized Freeze Dried Bone Allograft
NCT03992638 nacompletednot on this mapstarted 2019, after this paper: background citation

Mechanisms of LPRF Action in the Promotion of Wound Healing and Tissue Regeneration: A Randomised Controlled Trial

TypeinterventionalSponsorThe European Research Group on Periodontology (ERGOPerio)Ran2019 to 2022Enrolled12ConditionsGingival RecessionArmsleucocyte and platelet-rich fibrin (L-PRF) in combination with CAF, CAF
NCT06664268 early_phase1not yet recruitingnot on this mapstarted 2024, after this paper: background citation

Clinical and Ultrasound Assessment of Efficacy of Plasma Rich Fibrin (PRF) Injection and Fractional CO2 Laser in Treatment of Postburn Hypertrophic Scars: a Randomized Controlled Clinical Trial

TypeinterventionalSponsorAssiut UniversityRan2024 to 2025Enrolled30ConditionsHypertrophic Scars, Burn Scar PatientsArmsPlasma rich in growth factors (PRGF-Endoret), Fractional CO2 laser assisted PDT
NCT07351279 nanot yet recruitingnot on this mapstarted 2026, after this paper: background citation

" The Effect of Platelet Rich Fibrin On Sensitivity and Periodontal Pockets Distal to Second Molar After Surgical Extraction of Impacted Third Molar "

TypeinterventionalSponsorUniversity of Health Sciences LahoreRan2026 to 2028Enrolled56ConditionsThird Molar Impaction, Surgical Extraction of Impacted Third MolarsArmsPlatelet rich fibrin
3 · Its place in the literature

Who cites it

115 citing papers in PubMed, 19 syntheses or guidelines pooled it, 255 citations in OpenAlex.

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  16. Autologous platelet concentrates for treating periodontal infrabony defects.The Cochrane database of systematic reviews · 2018
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55 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

7 authors at 1 institution in 4 countries.

Ana B CastroDepartment of Oral Health Sciences, Periodontology, KU Leuven & Dentistry, University Hospitals Leuven, Leuven, Belgium.
Nastaran MeschiDepartment of Oral Health Sciences, Endodontology, KU Leuven & Dentistry, University Hospitals Leuven, Leuven, Belgium.
Andy TemmermanDepartment of Oral Health Sciences, Periodontology, KU Leuven & Dentistry, University Hospitals Leuven, Leuven, Belgium.
Nelson PintoDepartment of Oral Health Sciences, Periodontology, KU Leuven & Dentistry, University Hospitals Leuven, Leuven, Belgium.
Paul LambrechtsDepartment of Oral Health Sciences, Endodontology, KU Leuven & Dentistry, University Hospitals Leuven, Leuven, Belgium.
Wim TeughelsDepartment of Oral Health Sciences, Periodontology, KU Leuven & Dentistry, University Hospitals Leuven, Leuven, Belgium.
Marc QuirynenDepartment of Oral Health Sciences, Periodontology, KU Leuven & Dentistry, University Hospitals Leuven, Leuven, Belgium.
KU Leuven · BE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimTo analyse the regenerative potential of leucocyte- and platelet-rich fibrin (L-PRF) during periodontal surgery. MATERIALS AND

methodsAn electronic and hand search were conducted in three databases. Only randomized clinical trials were selected and no follow-up limitation was applied. Pocket depth (PD), clinical attachment level (CAL), bone fill, keratinized tissue width (KTW), recession reduction and root coverage (%) were considered as outcome. When possible, meta-analysis was performed.

resultsTwenty-four articles fulfilled the inclusion and exclusion criteria. Three subgroups were created: intra-bony defects (IBDs), furcation defects and periodontal plastic surgery. Meta-analysis was performed in all the subgroups. Significant PD reduction (1.1 ± 0.5 mm, p < 0.001), CAL gain (1.2 ± 0.6 mm, p < 0.001) and bone fill (1.7 ± 0.7 mm, p < 0.001) were found when comparing L-PRF to open flap debridement (OFD) in IBDs. For furcation defects, significant PD reduction (1.9 ± 1.5 mm, p = 0.01), CAL gain (1.3 ± 0.4 mm, p < 0.001) and bone fill (1.5 ± 0.3 mm, p < 0.001) were reported when comparing L-PRF to OFD. When L-PRF was compared to a connective tissue graft, similar outcomes were recorded for PD reduction (0.2 ± 0.3 mm, p > 0.05), CAL gain (0.2 ± 0.5 mm, p > 0.05), KTW (0.3 ± 0.4 mm, p > 0.05) and recession reduction (0.2 ± 0.3 mm, p > 0.05).

conclusionsL-PRF enhances periodontal wound healing.

Indexed as

LeukocytesPlatelet-Rich FibrinAlveolar Bone LossGuided Tissue Regeneration, PeriodontalHumansRandomized Controlled Trials as Topicbone regenerationgingival recessionintra-bony defectsleucocyte-platelet-rich fibrinopen flap debridementplatelet-rich fibrintissue regeneration

Identifiers

PMID27783851
PMCPMC5248642
OpenAlexW2543304149

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.