SynthesisPloS one2016
Neighborhood Deprivation and Risk of Congenital Heart Defects, Neural Tube Defects and Orofacial Clefts: A Systematic Review and Meta-Analysis.
Synthesis in PloS one, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Environmental and Genetic Risk Factors of Congenital Anomalies: an Umbrella Review of Systematic Reviews and Meta-Analyses.Journal of Korean medical science · 2021Pooled it
- A Mechanistic Review of Environmental Stressor to Decode Their Effect on Congenital Malformations: A Developmental Toxicity.Journal of biochemical and molecular toxicology · 2026Review
- Neural tube defects burden from 1992 to 2021: a global, regional, and national age-period-cohort analysis of disability-adjusted life years.BMC pediatrics · 2026Article
- Neighborhood-level deprivation measures in the United States: a scoping review and reference guide for investigators.BMC public health · 2026Article
- Amniotic Fluid Extracellular Vesicle Properties Evolve With Gestational Age and Reflect Fetal Development.Journal of extracellular biology · 2025Article
- Examining modification of the associations between air pollution and birth outcomes by neighborhood deprivation in a North Carolina birth cohort, 2011-2015.Frontiers in reproductive health · 2024Article
- Neighborhood social deprivation and healthcare utilization, disability, and comorbidities among young adults with congenital heart defects: Congenital heart survey to recognize outcomes, needs, and well-being 2016-2019.Birth defects research · 2023Article
- Association between maternal marginalization and infants born with congenital heart disease in Ontario Canada.BMC public health · 2023Article
- How are people with orofacial clefts attended in northwest region of São Paulo state, Brazil?Genetics and molecular biology · 2023Article
- Associations of congenital heart disease with deprivation index by rural-urban maternal residence: a population-based retrospective cohort study in Ontario, Canada.BMC pediatrics · 2022Article
- Regional variation in gastroschisis: a nationwide database review of demographics and outcomes.Pediatric surgery international · 2021Article
- Neighbourhood maternal socioeconomic status indicators and risk of congenital heart disease.BMC pregnancy and childbirth · 2021Article
- How Does Deprivation Affect Early-Age Mortality? Patterns of Socioeconomic Determinants of Neonatal and Postneonatal Mortality in Bolivia.Demography · 2020Article
- Association between neighborhood disadvantage and fulfillment of desired postpartum sterilization.BMC public health · 2020Article
- The impact of neighborhood to industrial areas on health in Uzbekistan: an ecological analysis of congenital diseases, infant mortality, and lung cancer.Environmental science and pollution research international · 2020Article
- Prevalence and Parental Risk Factors for Speech Disability Associated with Cleft Palate in Chinese Children-A National Survey.International journal of environmental research and public health · 2016Article
- Gestational folate deficiency alters embryonic gene expression and cell function.Differentiation; research in biological diversityArticle
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe conducted this systematic review and meta-analysis to address the open question of a possible association between the socioeconomic level of the neighborhoods in which pregnant women live and the risk of Congenital Heart Defects (CHDs), Neural Tube Defects (NTDs) and OroFacial Clefts (OFCs).
methodsWe searched MEDLINE from its inception to December 20th, 2015 for case-control, cohort and ecological studies assessing the association between neighborhood socioeconomic level and the risk of CHDs, NTDs and the specific phenotypes Cleft Lip with or without Cleft Palate (CLP) and Cleft Palate (CP). Study-specific risk estimates were pooled according to random-effect and fixed-effect models.
resultsOut of 245 references, a total of seven case-control studies, two cohort studies and two ecological studies were assessed in the systematic review; all studies were enrolled in the meta-analysis with the exception of the two cohort studies. No significant association has been revealed between CHDs or NTDs and neighborhood deprivation index. For CLP phenotype subgroups, we found a significantly higher rate in deprived neighborhoods (Odds Ratios (OR) = 1.22, 95% CI: 1.10, 1.36) whereas this was not significant for CP phenotype subgroups (OR = 1.20, 95%CI: 0.89, 1.61).
conclusionIn spite of the small number of epidemiological studies included in the present literature review, our findings suggest that neighborhood socioeconomic level where mothers live is associated only with an increased risk of CLP phenotype subgroups. This finding has methodological limitations that impede the formulation of firm conclusions, and further investigations should confirm this association.
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