ArticleAngewandte Chemie (International ed. in English)2016
Structural Snapshots for Mechanism-Based Inactivation of a Glycoside Hydrolase by Cyclopropyl Carbasugars.
Article in Angewandte Chemie (International ed. in English), 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
16 citing papers in PubMed, 36 citations in OpenAlex.
- Mechanism-Based Allylic Carbasugar Chlorides That Form Covalent Intermediates with α- and β-Galactosidases.Molecules (Basel, Switzerland) · 2024Article
- Development of Tunable Mechanism-Based Carbasugar Ligands that Stabilize Glycoside Hydrolases through the Formation of Transient Covalent Intermediates.ACS catalysis · 2024Article
- Activity-based metaproteomics driven discovery and enzymological characterization of potential α-galactosidases in the mouse gut microbiome.Communications chemistry · 2024Article
- Total Synthesis of Rameswaralide Utilizing a Pharmacophore-Directed Retrosynthetic Strategy.Journal of the American Chemical Society · 2022Article
- Synthesis of CFrontiers in chemistry · 2022Article
- Diversity-oriented synthesis of glycomimetics.Communications chemistry · 2021Article
- 2-Fluoro-5-nitrophenyldiazonium: A Novel Sanger-Type Reagent for the Versatile Functionalization of Alcohols.Chemistry (Weinheim an der Bergstrasse, Germany) · 2021Article
- Glycoside Hydrolases Restrict the Side Chain Conformation of Their Substrates To Gain Additional Transition State Stabilization.Journal of the American Chemical Society · 2020Article
- Glycoside hydrolase stabilization of transition state charge: new directions for inhibitor design.Chemical science · 2020Article
- Applications of alkyl orthoesters as valuable substrates in organic transformations, focusing on reaction media.RSC advances · 2020Review
- α-Galactosidase and Sucrose-Kinase Relationships in a Bi-functional AgaSK Enzyme Produced by the Human Gut SymbiontFrontiers in microbiology · 2020Article
- The transition to magic bullets - transition state analogue drug design.MedChemComm · 2018Review
- Revealing the mechanism for covalent inhibition of glycoside hydrolases by carbasugars at an atomic level.Nature communications · 2018Article
- The first crystal structure of a family 129 glycoside hydrolase from a probiotic bacterium reveals critical residues and metal cofactors.The Journal of biological chemistry · 2017Article
- Carba-cyclophellitols Are Neutral Retaining-Glucosidase Inhibitors.Journal of the American Chemical Society · 2017Article
- Structural Snapshots for Mechanism-Based Inactivation of a Glycoside Hydrolase by Cyclopropyl Carbasugars.Angewandte Chemie (International ed. in English) · 2016Article
Corrections and comments
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Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
Abstract
Glycoside hydrolases (GHs) have attracted considerable attention as targets for therapeutic agents, and thus mechanism-based inhibitors are of great interest. We report the first structural analysis of a carbocyclic mechanism-based GH inactivator, the results of which show that the two Michaelis complexes are in
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.