Evidence map›Paper›PMID 27783367›Full record

Trial reportObesity surgery2017

National Differences in Remission of Type 2 Diabetes Mellitus After Roux-en-Y Gastric Bypass Surgery-Subgroup Analysis of 2-Year Results of the Diabetes Surgery Study Comparing Taiwanese with Americans with Mild Obesity (BMI 30-35 kg/m

Keong Chong, Sayeed Ikramuddin, Wei-Jei Lee, Charles J Billington, John P Bantle, Qi Wang, Avis J Thomas, John E Connett, Daniel B Leslie, William B Inabnet and 12 more

Registry-linked trialAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Obesity surgery, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00641251 (Global Randomized Prospective Study of Intensive Medical Management of Type 2 Diabetes, With and Without Gastric Bypass Surgery), which is not on this map. Cited by 14 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00641251 nacompletednot on this map

Global Randomized Prospective Study of Intensive Medical Management of Type 2 Diabetes, With and Without Gastric Bypass Surgery

TypeinterventionalSponsorMedtronic - MITGRan2008 to 2016Enrolled120ConditionsType 2 Diabetes, Cardiovascular DiseaseArmsintensive medical management, RYGB & IMM
3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. How Do Trauma- and Violence-Informed Care Approaches Underpin Bariatric Surgery Interventions for Type 2 Diabetes Mellitus Remission? A Scoping Review.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Keong ChongDepartment of Medicine, Min-Sheng General Hospital, Taoyuan City, Taiwan.
Sayeed IkramuddinDepartment of Surgery, University of Minnesota, Minneapolis, MN, USA.
Wei-Jei LeeDepartment of Surgery, Min-Sheng General Hospital, Taoyuan City, Taiwan.
Charles J BillingtonDepartment of Medicine, Division of Endocrinology and Diabetes, University of Minnesota, Minneapolis, MN, USA.
John P BantleDepartment of Medicine, Division of Endocrinology and Diabetes, University of Minnesota, Minneapolis, MN, USA.
Qi WangDivision of Biostatistics, University of Minnesota, Minneapolis, MN, USA.
Avis J ThomasDivision of Biostatistics, University of Minnesota, Minneapolis, MN, USA.
John E ConnettDivision of Biostatistics, University of Minnesota, Minneapolis, MN, USA.
Daniel B LeslieDepartment of Surgery, University of Minnesota, Minneapolis, MN, USA.
William B InabnetDepartment of Surgery, Mount Sinai Beth Israel, New York, NY, USA.
Robert W JefferyDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Michael G SarrDepartment of Gastroenterologic and General Surgery, Mayo Clinic, Rochester, MN, USA.
Michael D JensenDepartment of Medicine, Division of Endocrinology and Diabetes, Mayo Clinic, Rochester, MN, USA.
Adrian VellaDepartment of Medicine, Division of Endocrinology and Diabetes, Mayo Clinic, Rochester, MN, USA.
Leaque AhmedDepartment of Surgery, Harlem Hospital Center, New York, NY, USA.
Kumar BelaniDepartment of Anesthesiology, University of Minnesota, Minneapolis, MN, USA.
Joyce L SchoneNutrition Services, Fairview Health System, Minneapolis, MN, USA.
Amy E OlofsonDepartment of Gastroenterologic and General Surgery, Mayo Clinic, Rochester, MN, USA.
Heather A BainbridgeDepartment of Bariatric Surgery, Temple University Hospital, Philadelphia, PA, USA.
Patricia S LaquaDivision of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, MN, USA.
Judith KornerDepartment of Medicine, Division of Endocrinology, Columbia University Medical Center, New York, NY, USA.
Lee-Ming ChuangDepartment of Medicine, National Taiwan University Hospital, Taipei, Taiwan. leeming@ntu.edu.tw.

Funding

University of Minnesota Clinical and Translational Science Institute (UMN CTSI)UL1TR002494 · NCATS · UNIVERSITY OF MINNESOTA · PI BLAZAR, BRUCE R, WEISDORF, DANIEL J · 2018 to 2022
$34.9M
NCATS NIH HHS UL1 TR002494
6 · The paper itself

Abstract

backgroundThe purpose of this study is to compare effects of different nations on Roux-en-Y gastric bypass (RYGB) vs. intensive medical management (IMM) in achieving remission of type 2 diabetes mellitus (T2DM). MATERIALS AND

methodsBetween April 2008 and December 2011, this randomized, controlled clinical trial was conducted at four teaching hospitals in the United States and Taiwan involving 71 participants with mild obesity (BMI 30-35 kg/m

resultsAt baseline, Taiwanese participants had a lower BMI, younger age, and shorter duration of T2DM than American participants. At 24 months, weight loss was greater in the RYGB group in both populations than in the IMM group. No IMM participant of either population had partial or complete remission of T2DM. In the RYGB group, a substantial proportion of the subjects achieved complete or partial remission (57 % in Taiwanese and 27 % in American participants, P = 0.08). Logistic regression revealed stimulated C-peptide (Odds ratio 2.22, P = 0.02) but not nationality as a significant predictor of diabetes remission.

conclusionAdding RYGB to lifestyle and medical management was associated with a greater likelihood of remission of T2DM in both Taiwanese and American subjects with mild obesity with type 2 diabetes. Residual beta-cell function at baseline appears to be the major factor predicting remission of T2DM. Trial registry number: clinicaltrials.gov Identifier: NCT00641251.

Indexed as

Gastric BypassAdultBody Mass IndexC-PeptideDiabetes Mellitus, Type 2FemaleHumansHypoglycemic AgentsLife StyleMaleMiddle AgedObesityRemission InductionTaiwanTime FactorsTreatment OutcomeC-PeptideHypoglycemic AgentsDiabetes remissionEthnic differencesNational differencesRoux-en-Y gastric bypassTaiwaneseType 2 diabetes mellitus

Identifiers

PMID27783367
PMCPMC5403871

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.