ArticleNeuroscience bulletin2016
Extracellular Signal-Regulated Kinase in Nucleus Accumbens Mediates Propofol Self-Administration in Rats.
Article in Neuroscience bulletin, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed.
- Microglial Activation Is Associated with Hippocampal Synaptic Degeneration and Cognitive Deficits Following Repeated Propofol Exposure.International journal of molecular sciences · 2026Article
- The Role of Toll-like Receptor 3 Signaling in Cognitive Impairment Induced by Propofol Addiction.Molecular neurobiology · 2025Article
- AMPA Receptor Within the Prelimbic Cortex Regulates Propofol-Induced Locomotor Sensitization.Addiction biology · 2025Article
- A comprehensive analysis of propofol abuse, addiction and neuropharmacological aspects: an updated review.Korean journal of anesthesiology · 2025Review
- Effect of Fospropofol Disodium on Perioperative Neurocognitive Function in Elderly Patients Undergoing Total Hip Arthroplasty.Drug design, development and therapy · 2025Article
- Effects of propofol on presynaptic synapsin phosphorylation in the mouse brain in vivo.Brain research · 2024Article
- Non-Opioid Anesthetics Addiction: A Review of Current Situation and Mechanism.Brain sciences · 2023Review
- The Adenosine A2A Receptor Activation in Nucleus Accumbens Suppress Cue-Induced Reinstatement of Propofol Self-administration in Rats.Neurochemical research · 2021Article
- Propofol but not dexmedetomidine produce locomotor sensitization via nitric oxide in rats.Psychopharmacology · 2021Article
- The Antagonism of Corticotropin-Releasing Factor Receptor-1 in Brain Suppress Stress-Induced Propofol Self-Administration in Rats.Frontiers in behavioral neuroscience · 2021Article
- Neurons in the Locus Coeruleus Modulate the Hedonic Effects of Sub-Anesthetic Dose of Propofol.Frontiers in neuroscience · 2021Article
- The role of NMDA receptors in rat propofol self-administration.BMC anesthesiology · 2020Article
- Effects of Electroacupuncture on Expression of D1 Receptor (D1R), Phosphorylation of Extracellular-Regulated Protein Kinase 1/2 (p-ERK1/2), and c-Fos in the Insular Cortex of Ketamine-Addicted Rats.Medical science monitor basic research · 2019Article
- Propofol Inhibits Androgen Production in Rat Immature Leydig Cells.Frontiers in pharmacology · 2019Article
- Drug addiction: a curable mental disorder?Acta pharmacologica Sinica · 2018Review
- Regulatory Effect of General Anesthetics on Activity of Potassium Channels.Neuroscience bulletin · 2018Review
- Atlas of the Striatum and Globus Pallidus in the Tree Shrew: Comparison with Rat and Mouse.Neuroscience bulletin · 2018Article
- Neurobiology of Propofol Addiction and Supportive Evidence: What Is the New Development?Brain sciences · 2018Review
- Metabolic Profiles of Propofol and Fospropofol: Clinical and Forensic Interpretative Aspects.BioMed research international · 2018Review
- ERK inhibition sensitizes CZ415-induced anti-osteosarcoma activityOncotarget · 2017Article
Corrections and comments
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Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Clinical and animal studies have indicated that propofol has potential for abuse, but the specific neurobiological mechanism underlying propofol reward is not fully understood. The purpose of this study was to investigate the role of extracellular signal-regulated kinase (ERK) signal transduction pathways in the nucleus accumbens (NAc) in propofol self-administration. We tested the expression of p-ERK in the NAc following the maintenance of propofol self-administration in rats. We also assessed the effect of administration of SCH23390, an antagonist of the D1 dopamine receptor, on the expression of p-ERK in the NAc in propofol self-administering rats, and examined the effects of intra-NAc injection of U0126, an MEK inhibitor, on propofol reinforcement in rats. The results showed that the expression of p-ERK in the NAc increased significantly in rats maintained on propofol, and pre-treatment with SCH23390 inhibited the propofol self-administration and diminished the expression of p-ERK in the NAc. Moreover, intra-NAc injection of U0126 (4 µg/side) attenuated the propofol self-administration. The data suggest that ERK signal transduction pathways coupled with D1 dopamine receptors in the NAc may be involved in the maintenance of propofol self-administration and its rewarding effects.
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