ArticleJournal of gastroenterology2017
Procalcitonin is a useful biomarker to predict severe acute cholangitis: a single-center prospective study.
Article in Journal of gastroenterology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 56 citations in OpenAlex.
- Risk factors for complications after laparoscopic surgery in children with congenital choledochal cysts.Translational pediatrics · 2026Article
- Association between anion gap trajectories and mortality in patients with acute cholangitis: a cohort study.Scientific reports · 2026Article
- Predictive Value of the Neutrophil‒Lymphocyte Ratio in the Risk Stratification and Prognosis for Patients with Acute Cholangitis: A Single-Center Retrospective Study.Journal of inflammation research · 2026Article
- Article
- Risk Factors for Common Bile Duct Stones in Patients with Previous Cholecystectomy: A Multicenter Prospective Proof-of-Concept Study.Journal of clinical medicine · 2025Article
- Predicting severity of inpatient acute cholangitis: combined neutrophil-to-lymphocyte ratio and prognostic nutritional index.BMC gastroenterology · 2024Article
- Nomogram for assistant diagnosing acute suppurative cholangitis: a case-control study.BMC gastroenterology · 2024Article
- ERCP endoscopic minimally invasive treatment of acute suppurative obstructive cholangitis: A study of 47 patients.Experimental and therapeutic medicine · 2024Article
- Elevated plasma and bile levels of corisin, a microbiota-derived proapoptotic peptide, in patients with severe acute cholangitis.Gut pathogens · 2023Article
- Proportion of Neutrophils in White Blood Cells as a Useful Marker for Predicting Bacteremic Acute Cholangitis.Internal medicine (Tokyo, Japan) · 2023Article
- Bile duct penetrating duodenal wall sign: a novel computed tomography finding of common bile duct stone impaction into duodenal major papilla.Japanese journal of radiology · 2023Article
- A Nomogram-Based Model for Predicting the Risk of Severe Acute Cholangitis Occurrence.International journal of general medicine · 2023Article
- Should lactate be added to Tokyo criteria for the evaluation of patients with acute cholangitis?Irish journal of medical science · 2022Article
- Procalcitonin to Predict Severity of Acute Cholangitis and Need for Urgent Biliary Decompression: Systematic Scoping Review.Journal of clinical medicine · 2022Article
- Clinical Significance of the Neutrophil-Lymphocyte Ratio as an Early Predictive Marker for Adverse Outcomes in Patients with Acute Cholangitis.Medicina (Kaunas, Lithuania) · 2022Article
- Role of Interventional Radiology in the Management of Acute Cholangitis.Seminars in interventional radiology · 2021Review
- Composite Inflammatory Indicators as Early Predictor of Intra-abdominal Infections after General Surgery.Journal of inflammation research · 2021Article
- Factors Associated with Mortality in Severe Acute Cholangitis in a Moroccan Intensive Care Unit: A Retrospective Analysis of 140 Cases.Gastroenterology research and practice · 2021Article
- Impact of the Sensitivity to Empiric Antibiotics on Clinical Outcomes after Biliary Drainage for Acute Cholangitis.Gut and liver · 2020Article
- Emergent Treatment of Acute Cholangitis and Acute Cholecystitis.Seminars in interventional radiology · 2020Review
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Authors and funding
15 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundProcalcitonin is being increasingly used to diagnose and grade acute systemic bacterial infection at an early stage of disease onset. The aim of this prospective study was to evaluate the usefulness of procalcitonin for severity grading of acute cholangitis on patient admission.
methodsPatients with acute cholangitis were prospectively enrolled. The severity of acute cholangitis was graded on the basis of the 2013 Tokyo guidelines (Japanese Society of Hepato-Biliary-Pancreatic Surgery, 2013). We compared the ability of procalcitonin level on admission to predict moderate/severe (vs mild) or severe (vs mild/moderate) acute cholangitis with the abilities of white blood cell (WBC) count and C-reactive protein (CRP) level.
resultsTwo hundred thirteen patients were analyzed, and the severity of acute cholangitis was graded as mild, moderate, and severe in 108, 76, and 29 patients respectively. Procalcitonin level, WBC count, and CRP level all increased significantly according to the severity. In the receiver operating characteristic analyses, the area under the curve for procalcitonin for severe acute cholangitis was 0.90 [95% confidence interval (CI) 0.85-0.96] and was significantly greater than that for WBC (0.62; 95% CI 0.48-0.76) and that for CRP (0.70; 95% CI 0.60-0.80). The optimal cutoff value for procalcitonin for prediction of severe acute cholangitis was 2.2 ng/mL (sensitivity 0.97; specificity 0.73; accuracy 0.77). The areas under the curve for procalcitonin, WBC, and CRP for moderate/severe acute cholangitis were not significantly different.
conclusionsProcalcitonin predicted severe acute cholangitis better than conventional biomarkers. Severe cases for which urgent biliary drainage is indicated might be identified on admission on the basis of the cutoff values for procalcitonin suggested in this study.
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