Evidence map›Paper›PMID 27783100›Full record

ArticleNeuroradiology2016

Micro-structural white matter abnormalities in type 2 diabetic patients: a DTI study using TBSS analysis.

Xin Tan, Peng Fang, Jie An, Huan Lin, Yi Liang, Wen Shen, Xi Leng, Chi Zhang, Yanting Zheng, Shijun Qiu

Registry-linked trialAbstract read
PubMed Publisher
In one paragraph

Article in Neuroradiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06322212 (Type 2 Diabetes Mellitus and Blood Brain Barrier Improvement - A Randomized Clinical Trial), which is not on this map. Cited by 28 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06322212 early_phase1recruitingnot on this mapstarted 2024, after this paper: background citation

Type 2 Diabetes Mellitus and Blood Brain Barrier Improvement - A Randomized Clinical Trial

TypeinterventionalSponsorUniversity of California, Los AngelesRan2024 to 2027Enrolled52ConditionsType2diabetesArmsThiamine, Placebo
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
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  15. Diabetes Mellitus-Related Dysfunction of the Motor System.International journal of molecular sciences · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xin TanMedical Imaging Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, No.16 Jichang Road, Guangdong, China.
Peng FangCollege of Mechatronics and Automation, National University of Defense Technology, Hunan, China.
Jie AnMedical Imaging Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, No.16 Jichang Road, Guangdong, China.
Huan LinMedical Imaging Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, No.16 Jichang Road, Guangdong, China.
Yi LiangMedical Imaging Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, No.16 Jichang Road, Guangdong, China.
Wen ShenMedical Imaging Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, No.16 Jichang Road, Guangdong, China.
Xi LengMedical Imaging Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, No.16 Jichang Road, Guangdong, China.
Chi ZhangMedical Imaging Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, No.16 Jichang Road, Guangdong, China.
Yanting ZhengMedical Imaging Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, No.16 Jichang Road, Guangdong, China.
Shijun QiuMedical Imaging Center, The First Affiliated Hospital of Guangzhou University of Chinese Medicine, No.16 Jichang Road, Guangdong, China. qiushijun006@sina.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionPatients with type 2 diabetes mellitus (T2DM) have usually been found cognitive impairment associated with brain white matter (WM) abnormalities. However, findings have varied across studies, and any potential relationship with Alzheimer's disease (AD) remains unclear. The aim of this study was to assess the whole-brain WM integrity of T2DM patients and to compare our findings with those of published AD cases.

methodsIn this study, we used diffusion tensor imaging (DTI) combined with tract-based spatial statistics (TBSS) to investigate whole-brain WM abnormalities in 48 T2DM patients and 48 healthy controls. The effects of age and gender were also evaluated.

resultsIn our study, significantly decreasing FA and increasing MD and DA values (P<0.05) were found in some WM regions closely related to the default mode network (DMN), including cingulum, the right frontal lobe involving the right uncinate fasciculus (UF), bilateral parietal lobes involving the superior longitudinal fasciculus (SLF) and the inferior longitudinal fasciculus (ILF), and the right middle temporal gyrus (MTG) involving the UF and the ILF. We also found abnormalities in the thalamus involving the fornix (FX), anterior thalamic radiation (ATR), and posterior thalamic radiation (PTR). The damaged regions above are similar to those found in patients with AD, as reported in previous studies.

conclusionThe present study not only provides useful information about the WM regions and tracts affected by T2DM but also offers insight into the underlying neuropathological process in T2DM patients and the relationship between T2DM and AD.

Indexed as

Alzheimer DiseaseBrainDiabetes Mellitus, Type 2Diffusion Tensor ImagingFemaleHumansImage Interpretation, Computer-AssistedLeukoencephalopathiesMaleMiddle AgedReproducibility of ResultsSensitivity and SpecificityWhite MatterDefault mode networkDiffusion tensor imagingThalamusTract-based spatial statisticsType 2 diabetes mellitus

Identifiers

PMID27783100

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.