ArticleNature medicine2016
The search for imaging biomarkers in psychiatric disorders.
Article in Nature medicine, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 118 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
118 citing papers in PubMed, 6 syntheses or guidelines pooled it.
- Artificial intelligence approaches for schizophrenia prediction and its biomarkers using medical imaging data.Frontiers in psychiatry · 2026Pooled it
- Pharmaco-psychiatry and gut microbiome: a systematic review of effects of psychotropic drugs for bipolar disorder.Microbiology (Reading, England) · 2025Pooled it
- Quantitative analysis of literature on diagnostic biomarkers of Schizophrenia: revealing research hotspots and future prospects.BMC psychiatry · 2025Pooled it
- Magnetic resonance imaging-based machine learning classification of schizophrenia spectrum disorders: a meta-analysis.Psychiatry and clinical neurosciences · 2024Pooled it
- Biomarkers and Tourette syndrome: a systematic review and meta-analysis.Frontiers in neurology · 2024Pooled it
- Neuromelanin accumulation in patients with schizophrenia: A systematic review and meta-analysis.Neuroscience and biobehavioral reviews · 2022Pooled it
- A robust and reproducible connectome fingerprint of ketamine is highly associated with the connectomic signature of antidepressants.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Trial
- Quantitative Electroencephalography as a Complement to Symptom-Based Psychiatric Diagnosis: A Narrative Review.Journal of personalized medicine · 2026Review
- Inferring relationships among major psychiatric disorders in a resting-state functional connectivity-informed embedding space.NPJ systems biology and applications · 2026Article
- Grey matter volume associations with personality functioning in a clinical cohort of female youths.NeuroImage. Clinical · 2026Article
- Identification of AICD-associated transcriptomic markers in major depressive disorder.Frontiers in psychiatry · 2026Article
- From Monoamines to Systems Psychiatry: Rewiring Depression Science and Care (1960s-2025).Biomedicines · 2025Article
- Special Issue "Translating Molecular Psychiatry: From Biomarkers to Personalized Therapies".International journal of molecular sciences · 2025Article
- Investigating dopaminergic abnormalities in schizophrenia and first-episode psychosis with normative modelling and multisite molecular neuroimaging.Molecular psychiatry · 2025Article
- The GREENBEAN checklist for reporting studies evaluating the effectiveness of EEG-based biomarkers.Clinical neurophysiology : official journal of the International Federation of Clinical Neurophysiology · 2025Review
- Towards precision MRI biomarkers in epilepsy with normative modelling.Brain : a journal of neurology · 2025Review
- Transdiagnostic Symptom Domains Have Distinct Patterns of Association With Head Motion During Multimodal Imaging in Children.Biological psychiatry global open science · 2025Article
- Mechanistic and Predictive Implications of Transdiagnostic Features of the Connectome.Biological psychiatry · 2025Article
- Multivariate patterns among multimodal neuroimaging and clinical, cognitive, and daily functioning characteristics in bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Imaging Biomarker Studies of Antipsychotic-Naïve First-Episode Schizophrenia in China: Progress and Future Directions.Schizophrenia bulletin · 2025Review
58 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The field of medicine is moving toward the use of biomarkers for the optimization of individualized care. This is a particular challenge for the field of psychiatry, in which diagnosis is based on a descriptive collection of behaviors without the availability of any objective test to stratify patients. Neuroimaging techniques such as molecular imaging with positron-emission tomography (PET) or structural and functional magnetic resonance imaging (MRI) provide an opportunity to bring psychiatry from an era of subjective descriptive classification into objective and tangible brain-based measures. Here we provide steps toward the development of robust, reliable and valid biomarkers. The success of such development is crucial because it will enable the field of psychiatry to move forward into the era of modern medicine.
Indexed as
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27783066What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.