Evidence map›Paper›PMID 27783051›Full record

SynthesisInternational journal of molecular sciences2016

The Efficacy of Non-Pharmacological Interventions on Brain-Derived Neurotrophic Factor in Schizophrenia: A Systematic Review and Meta-Analysis.

Kenji Sanada, Iñaki Zorrilla, Yusuke Iwata, Cristina Bermúdez-Ampudia, Ariel Graff-Guerrero, Mónica Martínez-Cengotitabengoa, Ana González-Pinto

Open access · goldAbstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 4 pooled it
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 4 syntheses or guidelines pooled it, 33 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. A Multicentre, Randomised, Controlled Trial of a Combined Clinical Treatment for First-Episode Psychosis.International journal of environmental research and public health · 2021
    Trial
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Review
  14. Review
  15. Review
  16. Article
  17. Article
  18. Exercise and Schizophrenia.Advances in experimental medicine and biology · 2020
    Review
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 3 countries.

Kenji SanadaCIBERSAM, BioAraba Research Institute, OSI Araba, Department of Psychiatry, Araba University Hospital, University of the Basque Country (EHU/UPV), Olaguibel Street 29, Vitoria 01004, Spain. ksanappu@gmail.com.
Iñaki ZorrillaCIBERSAM, BioAraba Research Institute, OSI Araba, Department of Psychiatry, Araba University Hospital, University of the Basque Country (EHU/UPV), Olaguibel Street 29, Vitoria 01004, Spain. inaki.zorrillamartinez@osakidetza.eus.
Yusuke IwataMultimodal Imaging Group-Research Imaging Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON M5T 1R8, Canada. yusuke.iwata2010@gmail.com.
Cristina Bermúdez-AmpudiaCIBERSAM, BioAraba Research Institute, OSI Araba, Department of Psychiatry, Araba University Hospital, University of the Basque Country (EHU/UPV), Olaguibel Street 29, Vitoria 01004, Spain. cristina.bermudezampudia@osakidetza.eus.
Ariel Graff-GuerreroMultimodal Imaging Group-Research Imaging Centre, Centre for Addiction and Mental Health, 250 College Street, Toronto, ON M5T 1R8, Canada. ariel_graff@yahoo.com.mx.
Mónica Martínez-CengotitabengoaCIBERSAM, BioAraba Research Institute, OSI Araba, Department of Psychiatry, Araba University Hospital, University of the Basque Country (EHU/UPV), Olaguibel Street 29, Vitoria 01004, Spain. monica.martinezcengotitabengoa@osakidetza.eus.
Ana González-PintoCIBERSAM, BioAraba Research Institute, OSI Araba, Department of Psychiatry, Araba University Hospital, University of the Basque Country (EHU/UPV), Olaguibel Street 29, Vitoria 01004, Spain. anamaria.gonzalez-pintoarrillaga@osakidetza.eus.
University of the Basque Country · ESCentre for Addiction and Mental Health · CAHospital Universitario Araba · ESShowa University · JPUniversity of Toronto · CA

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Several studies have investigated the relationship between non-pharmacological interventions (NPIs) and peripheral brain-derived neurotrophic factor (BDNF) in schizophrenia patients. We conducted a systematic review and meta-analysis to review the efficacy of NPIs on peripheral serum and plasma BDNF in subjects with schizophrenia (including schizoaffective disorder). Meta-analyses were conducted to examine the effects of NPIs on blood BDNF levels by using the standardized mean differences (SMDs) between the intervention groups and controls. In total, six randomized controlled trials with 289 participants were included. Of them, five studies used exercise, physical training or diet products. One study used cognitive training. Overall, the BDNF levels in the NPI group increased significantly compared with the control groups (SMD = 0.95, 95% confidence interval (CI) = 0.07 to 1.83,

Indexed as

Brain-Derived Neurotrophic FactorCognitive Behavioral TherapyDiet TherapyExercise TherapyHumansSchizophreniaBDNF protein, humanBrain-Derived Neurotrophic Factorbrain-derived neurotrophic factor (BDNF)meta-analysesnon-pharmacological interventionsrandomized controlled trialsschizophrenia

Identifiers

PMID27783051
PMCPMC5085790
OpenAlexW2537573550

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.