Evidence map›Paper›PMID 27782962›Full record

SynthesisJournal of pediatric gastroenterology and nutrition2017

Causal Evaluation of Acute Recurrent and Chronic Pancreatitis in Children: Consensus From the INSPPIRE Group.

Cheryl E Gariepy, Melvin B Heyman, Mark E Lowe, John F Pohl, Steven L Werlin, Michael Wilschanski, Bradley Barth, Douglas S Fishman, Steven D Freedman, Matthew J Giefer and 9 more

Registry-linked trialAbstract readConsensus StatementSystematic Review
In one paragraph

Synthesis in Journal of pediatric gastroenterology and nutrition, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03672422 (Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer), which is not on this map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
7.5field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03672422 completednot on this map

Consortium for the Study of Chronic Pancreatitis, Diabetes, and Pancreatic Cancer (CPDPC) CPDPC16-03 Pediatric Longitudinal Cohort Study of Chronic Pancreatitis

Typeobservational_patient_registrySponsorAliye UcRan2017 to 2020Enrolled623ConditionsPancreatitis, Chronic, Pancreatitis, AcuteArmsBlood sample, Patient questionnaires, Saliva sample, Urine sample
3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 84 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 14 institutions in 4 countries.

Cheryl E Gariepy*Nationwide Children's Hospital and The Ohio State University, Columbus †University of California at San Francisco, San Francisco ‡Children's Hospital of Pittsburgh of UPMC, Pittsburgh, PA §University of Utah, Salt Lake City ||Medical College of Wisconsin, Milwaukee ¶Hadassah-Hebrew University Medical Center, Jerusalem, Israel #University of Texas, Southwestern Medical School, Dallas **Baylor College of Medicine, Houston, TX ††Harvard Medical School, Boston, MA ‡‡Seattle Children's Hospital, Seattle, WA §§Hospital for Sick Children, Toronto, ON ||||Montreal Children's Hospital, McGill University, Montreal, QC, Canada ¶¶University of New South Wales and Sydney Children's Hospital Randwick, Sydney, Australia ##University of Minnesota, Masonic Children's Hospital, Minneapolis ***University of Iowa, Children's Hospital, Iowa City.
Melvin B Heyman
Mark E Lowe
John F Pohl
Steven L Werlin
Michael Wilschanski
Bradley Barth
Douglas S Fishman
Steven D Freedman
Matthew J Giefer
Tanja Gonska
Ryan Himes
Sohail Z Husain
Veronique D Morinville
Chee Y Ooi
Sarah J Schwarzenberg
David M Troendle
Elizabeth Yen
Aliye Uc
Baylor College of Medicine · USChildren's Hospital of Pittsburgh · USThe University of Texas Southwestern Medical Center · USHadassah Medical Center · ILHarvard University · USHospital for Sick Children · CAMedical College of Wisconsin · USMontreal Children's Hospital · CASeattle Children's Hospital · USThe Ohio State University · USUniversity of Iowa Stead Family Children’s Hospital · USUniversity of Minnesota Children's Hospital · USUniversity of Utah · USUNSW Sydney · AU

Funding

Tumor Microenvironment and Cancer ImmunologyP30CA030199 · NCI · SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE · PI ELENA B PASQUALE · 1985 to 2026
$107.2M
Vector Core-Core 2P30DK054759 · NIDDK · UNIVERSITY OF IOWA · PI Amy Leanne Ryan · 1998 to 2026
$30.5M
Year 9 Administrative Supplement to INSPPIRE 2U01DK108334 · NIDDK · UNIVERSITY OF IOWA · PI MARK E. LOWE, Aliye Uc · 2015 to 2026
$10.5M
University of Iowa Clinical and Translational Science ProgramUL1TR000442 · NCATS · UNIVERSITY OF IOWA · PI ROSENTHAL, GARY E · 2012 to 2013
$10.0M
The Ohio State University Pancreatic Disorders Network (OSU-PDN)U01DK108327 · NIDDK · OHIO STATE UNIVERSITY · PI CONWELL, DARWIN LEWIS, HART, PHILIP A. · 2015 to 2024
$5.5M
DYSBIOTIC MICROBIOME IN PANCREATITIS, DIABETES, AND PANCREATIC CANCERU01DK108326 · NIDDK · BAYLOR COLLEGE OF MEDICINE · PI FISHER, WILLIAM E · 2015 to 2024
$5.2M
INSPPIRE TO STUDY ACUTE RECURRENT AND CHRONIC PANCREATITIS IN CHILDRENR21DK096327 · NIDDK · UNIVERSITY OF IOWA · PI UC, ALIYE · 2012 to 2014
$586k
NCATS NIH HHS UL1 TR000442NIDDK NIH HHS P30 DK054759NIDDK NIH HHS R21 DK096327NIDDK NIH HHS U01 DK108326NIDDK NIH HHS U01 DK108327NIDDK NIH HHS U01 DK108334
6 · The paper itself

Abstract

objectivesAcute recurrent pancreatitis (ARP) and chronic pancreatitis (CP) have been diagnosed in children at increasing rates during the past decade. As pediatric ARP and CP are still relatively rare conditions, little quality evidence is available on which to base the diagnosis and determination of etiology. The aim of the study was to review the current state of the literature regarding the etiology of these disorders and to developed a consensus among a panel of clinically active specialists caring for children with these disorders to help guide the diagnostic evaluation and identify areas most in need of future research.

methodsA systematic review of the literature was performed and scored for quality, followed by consensus statements developed and scored by each individual in the group for level of agreement and strength of the supporting data using a modified Delphi method. Scores were analyzed for the level of consensus achieved by the group.

resultsThe panel reached consensus on 27 statements covering the definitions of pediatric ARP and CP, evaluation for potential etiologies of these disorders, and long-term monitoring. Statements for which the group reached consensus to make no recommendation or could not reach consensus are discussed.

conclusionsThis consensus helps define the minimal diagnostic evaluation and monitoring of children with ARP and CP. Even in areas in which we reached consensus, the quality of the evidence is weak, highlighting the need for further research. Improved understanding of the underlying cause will facilitate treatment development and targeting.

Indexed as

ConsensusPediatricsAcute DiseaseChildDelphi TechniqueHumansPancreatitisPancreatitis, ChronicRecurrence

Identifiers

PMID27782962
PMCPMC5191966
OpenAlexW2539876694

What OpenQuestion holds

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Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.