Evidence map›Paper›PMID 27782885›Full record

ArticleeLife2016

γ-Protocadherin structural diversity and functional implications.

Kerry Marie Goodman, Rotem Rubinstein, Chan Aye Thu, Seetha Mannepalli, Fabiana Bahna, Göran Ahlsén, Chelsea Rittenhouse, Tom Maniatis, Barry Honig, Lawrence Shapiro

Abstract read
In one paragraph

Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
43citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

43 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Structural Insights into Ordered Multicomponent Assemblies in Cell Junctions.Advances in experimental medicine and biology · 2026
    Review
  5. Surface delivery quantification reveals distinct trafficking efficiencies among clustered protocadherin isoforms.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  6. Article
  7. Article
  8. Clustered protocadherinProceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  9. Article
  10. Visualization ofProceedings of the National Academy of Sciences of the United States of America · 2023
    Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Adhesion-Based Self-Organization in Tissue Patterning.Annual review of cell and developmental biology · 2022
    Review
  16. On the formation of ordered protein assemblies in cell-cell interfaces.Proceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  17. Article
  18. Article
  19. Article
  20. Mouse models for the study of clustered protocadherins.Current topics in developmental biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kerry Marie GoodmanDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, United States.
Rotem RubinsteinDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, United States.
Chan Aye ThuDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, United States.
Seetha MannepalliDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, United States.
Fabiana BahnaDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, United States.
Göran AhlsénDepartment of Systems Biology, Columbia University, New York, United States.
Chelsea RittenhouseDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, United States.
Tom ManiatisDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, United States.
Barry HonigDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, United States.ORCID 0000-0002-2480-6696
Lawrence ShapiroDepartment of Biochemistry and Molecular Biophysics, Columbia University, New York, United States.ORCID 0000-0001-9943-8819

Funding

Overall EvaluationP41GM103403 · NIGMS · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2012 to 2017
$14.3M
MOLECULAR BASIS OF CADHERIN MEDIATED CELL ADHESIONR01GM062270 · NIGMS · MOUNT SINAI SCHOOL OF MEDICINE OF NYU · PI SHAPIRO, LAWRENCE S · 2001 to 2015
$3.4M
High-performance compute cluster for biomedical computingS10OD012351 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CALIFANO, ANDREA · 2012 to 2012
$2.0M
The structural basis of cis and trans protocadherin interactionsR01GM107571 · NIGMS · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI MANIATIS, THOMAS P, SHAPIRO, LAWRENCE S · 2013 to 2016
$1.8M
Storage System for High Performance ComputingS10OD021764 · OD · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI CALIFANO, ANDREA · 2016 to 2016
$600k
Howard Hughes Medical InstituteNIGMS NIH HHS P41 GM103403NIGMS NIH HHS R01 GM062270NIGMS NIH HHS R01 GM107571NIH HHS S10 OD012351NIH HHS S10 OD021764
6 · The paper itself

Abstract

Stochastic cell-surface expression of α-, β-, and γ-clustered protocadherins (Pcdhs) provides vertebrate neurons with single-cell identities that underlie neuronal self-recognition. Here we report crystal structures of ectodomain fragments comprising cell-cell recognition regions of mouse γ-Pcdhs γA1, γA8, γB2, and γB7 revealing

Indexed as

AnimalsCadherin Related ProteinsCadherinsCrystallography, X-RayMiceModels, MolecularProtein ConformationProtein IsoformsProtein MultimerizationCadherin Related ProteinsCadherinsGamma-protocadherinsProtein Isoformsbiophysicsclustered protocadherinscrystal structuremouseneuronal self-avoidanceneuroscienceprotein diversityprotein-protein recognitionstructural biology

Identifiers

PMID27782885
PMCPMC5106212

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.