ArticleeLife2016
Lognormal firing rate distribution reveals prominent fluctuation-driven regime in spinal motor networks.
Article in eLife, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 41 papers.
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Who cites it
41 citing papers in PubMed.
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- Motor unit mechanisms of speed control in mouse locomotion.bioRxiv : the preprint server for biology · 2025Article
- The dorsal column nuclei encode and transmit the network signatures of mechanical allodynia.Cell reports · 2025Article
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- Intrathecal delivery of BDNF to the lumbar spinal cord modulates lumbar interneurons activity in a feline model of spinal cord injury.Journal of neural engineering · 2025Article
- Cellular-resolution optogenetics reveals attenuation-by-suppression in visual cortical neurons.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- Conductance-based dendrites perform Bayes-optimal cue integration.PLoS computational biology · 2024Article
- Single-cell optogenetics reveals attenuation-by-suppression in visual cortical neurons.bioRxiv : the preprint server for biology · 2024Article
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- Stochastic resonance in sparse neuronal network: functional role of ongoing activity to detect weak sensory input in awake auditory cortex of rat.Cerebral cortex (New York, N.Y. : 1991) · 2024Article
- Endothelial cell SMAD6 balances Alk1 function to regulate adherens junctions and hepatic vascular development.Development (Cambridge, England) · 2023Article
- Logarithmically scaled, gamma distributed neuronal spiking.The Journal of physiology · 2023Review
- Monosynaptic trans-collicular pathways link mouse whisker circuits to integrate somatosensory and motor cortical signals.PLoS biology · 2023Article
- Endothelial Cell SMAD6 Balances ACVRL1/Alk1 Function to Regulate Adherens Junctions and Hepatic Vascular Development.bioRxiv : the preprint server for biology · 2023Article
- Microcircuit Synchronization and Heavy-Tailed Synaptic Weight Distribution Augment preBötzinger Complex Bursting Dynamics.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
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- Single-cell and ensemble activity of lumbar intermediate and ventral horn interneurons in the spinal air-stepping cat.Journal of neurophysiology · 2022Article
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Abstract
When spinal circuits generate rhythmic movements it is important that the neuronal activity remains within stable bounds to avoid saturation and to preserve responsiveness. Here, we simultaneously record from hundreds of neurons in lumbar spinal circuits of turtles and establish the neuronal fraction that operates within either a 'mean-driven' or a 'fluctuation-driven' regime. Fluctuation-driven neurons have a 'supralinear' input-output curve, which enhances sensitivity, whereas the mean-driven regime reduces sensitivity. We find a rich diversity of firing rates across the neuronal population as reflected in a lognormal distribution and demonstrate that half of the neurons spend at least 50 % of the time in the 'fluctuation-driven' regime regardless of behavior. Because of the disparity in input-output properties for these two regimes, this fraction may reflect a fine trade-off between stability and sensitivity in order to maintain flexibility across behaviors.
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