Evidence map›Paper›PMID 27782836›Full record

ArticleParticle and fibre toxicology2016

Macrophage-derived MCPIP1 mediates silica-induced pulmonary fibrosis via autophagy.

Haijun Liu, Shencun Fang, Wei Wang, Yusi Cheng, Yingming Zhang, Hong Liao, Honghong Yao, Jie Chao

Abstract read
In one paragraph

Article in Particle and fibre toxicology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed.

  1. Monocyte-mediated mechanisms in idiopathic pulmonary fibrosis: opportunities for early intervention.Apoptosis : an international journal on programmed cell death · 2026
    Review
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  17. Macrophage Autophagy and Silicosis: Current Perspective and Latest Insights.International journal of molecular sciences · 2021
    Review
  18. Review
  19. Article
  20. International journal of medical sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Haijun LiuDepartment of Physiology, School of Medicine, Southeast University, 87 Dingjiaqiao Rd, Nanjing, Jiangsu, 210009, China.
Shencun FangNine Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, Jiangsu, 210029, China.
Wei WangNine Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, Jiangsu, 210029, China.
Yusi ChengDepartment of Physiology, School of Medicine, Southeast University, 87 Dingjiaqiao Rd, Nanjing, Jiangsu, 210009, China.
Yingming ZhangNine Department of Respiratory Medicine, Nanjing Chest Hospital, Nanjing, Jiangsu, 210029, China.
Hong LiaoNeurobiology Laboratory, New Drug Screening Centre, China Pharmaceutical University, Nanjing, Jiangsu, 210009, China.
Honghong YaoDepartment of Pharmacology, School of Medicine, Southeast University, 87 Dingjiaqiao Rd, Nanjing, Jiangsu, 210009, China. yaohh@seu.edu.cn.
Jie ChaoDepartment of Physiology, School of Medicine, Southeast University, 87 Dingjiaqiao Rd, Nanjing, Jiangsu, 210009, China. chaojie@seu.edu.cn.ORCID 0000-0002-7800-3557

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundSilicosis is characterized by accumulation of fibroblasts and excessive deposition of extracellular matrix. Monocyte chemotactic protein-1-induced protein 1 (MCPIP1) plays a critical role in fibrosis induced by SiO

resultsExperiments using primary cultures of alveolar macrophages from healthy donors and silicosis patients as well as differentiated U937 macrophages demonstrated the following results: 1) SiO

conclusionsOur results elucidated a link between SiO

Indexed as

ApoptosisAutophagyHumansMacrophagesPulmonary FibrosisRibonucleasesRNA, Small InterferingSignal TransductionSilicon DioxideTranscription FactorsTumor Suppressor Protein p53U937 CellsRibonucleasesRNA, Small InterferingSilicon DioxideTP53 protein, humanTranscription FactorsTumor Suppressor Protein p53ZC3H12A protein, humanAutophagyMCPIP1Migrationp53Silicosis

Identifiers

PMID27782836
PMCPMC5078901

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.