ArticleStatistics in medicine2017
Weighted analysis of composite endpoints with simultaneous inference for flexible weight constraints.
Article in Statistics in medicine, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Association between frailty and clinical outcomes in patients undergoing craniotomy-systematic review and meta-analysis of observational studies.Systematic reviews · 2024Pooled it
- Composite endpoint to evaluate complement inhibition therapy in patients with paroxysmal nocturnal hemoglobinuria.European journal of haematology · 2022Article
- Improving Visualization Methods of Utility-Weighted Disability Outcomes for Stroke Trials.Frontiers in neurology · 2022Article
- Using a Composite Maternal-Infant Outcome Measure in Tuberculosis-Prevention Studies Among Pregnant Women.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021Article
- A framework for considering the risk-benefit trade-off in designing noninferiority trials using composite outcome approaches.Statistics in medicine · 2021Article
- Article
- Choosing primary endpoints for clinical trials of health care interventions.Contemporary clinical trials communications · 2019Review
- Multistate modeling and simulation of patient trajectories after allogeneic hematopoietic stem cell transplantation to inform drug development.Biometrical journal. Biometrische Zeitschrift · 2019Article
- Prevalence of asthma among the adult general population of five Middle Eastern countries: results of the SNAPSHOT program.BMC pulmonary medicine · 2018Article
- Using perinatal morbidity scoring tools as a primary study outcome.Journal of epidemiology and community health · 2017Article
- Weighted analysis of composite endpoints with simultaneous inference for flexible weight constraints.Statistics in medicine · 2017Article
Corrections and comments
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Authors and funding
2 authors.
Funding
Abstract
Composite endpoints are widely used as primary endpoints of randomized controlled trials across clinical disciplines. A common critique of the conventional analysis of composite endpoints is that all disease events are weighted equally, whereas their clinical relevance may differ substantially. We address this by introducing a framework for the weighted analysis of composite endpoints and interpretable test statistics, which are applicable to both binary and time-to-event data. To cope with the difficulty of selecting an exact set of weights, we propose a method for constructing simultaneous confidence intervals and tests that asymptotically preserve the family-wise type I error in the strong sense across families of weights satisfying flexible inequality or order constraints based on the theory of χ¯2-distributions. We show that the method achieves the nominal simultaneous coverage rate with substantial efficiency gains over Scheffé's procedure in a simulation study and apply it to trials in cardiovascular disease and enteric fever. © 2016 The Authors. Statistics in Medicine Published by John Wiley & Sons Ltd.
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