ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2017
Network-Level Dysconnectivity in Drug-Naïve First-Episode Psychosis: Dissociating Transdiagnostic and Diagnosis-Specific Alterations.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 4 of them syntheses that pooled it.
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Who cites it
37 citing papers in PubMed, 4 syntheses or guidelines pooled it.
- Spontaneous Brain Activity Alterations in First-Episode Psychosis: A Meta-analysis of Functional Magnetic Resonance Imaging Studies.Schizophrenia bulletin · 2023Pooled it
- Shared and distinct brain fMRI response during performance of working memory tasks in adult patients with schizophrenia and major depressive disorder.Human brain mapping · 2021Pooled it
- Neural correlates of emotional processing in psychosis risk and onset - A systematic review and meta-analysis of fMRI studies.Neuroscience and biobehavioral reviews · 2021Pooled it
- Dysconnectivity of Large-Scale Functional Networks in Early Psychosis: A Meta-analysis.Schizophrenia bulletin · 2019Pooled it
- Higher-order functional brain networks and anterior cingulate glutamate + glutamine (Glx) in antipsychotic-naïve first episode psychosis patients.Translational psychiatry · 2024Trial
- Functional Coupling and Longitudinal Outcome Prediction in First-Episode Psychosis.Biological psychiatry global open science · 2025Article
- Over-integration of visual network in major depressive disorder and its association with gene expression profiles.Translational psychiatry · 2025Article
- Interpretable and integrative deep learning for discovering brain-behaviour associations.Scientific reports · 2025Article
- Classification of psychosis spectrum disorders using graph convolutional networks with structurally constrained functional connectomes.Neural networks : the official journal of the International Neural Network Society · 2025Article
- Static and Dynamic Dysconnectivity in Early Psychosis: Relationship With Symptom Dimensions.Schizophrenia bulletin · 2024Article
- Unveiling Promising Neuroimaging Biomarkers for Schizophrenia Through Clinical and Genetic Perspectives.Neuroscience bulletin · 2024Review
- Common and divergent neuroimaging features in major depression, posttraumatic stress disorder, and their comorbidity.Psychoradiology · 2024Review
- Aberrant brain dynamics of large-scale functional networks across schizophrenia and mood disorder.NeuroImage. Clinical · 2024Article
- Resting-State Functional Connectivity Explained Psychotic-like Experiences in the General Population and Partially Generalized to Patients and Relatives.Biological psychiatry global open science · 2023Article
- Aberrant cortico-thalamo-cerebellar network interactions and their association with impaired cognitive functioning in patients with schizophrenia.Schizophrenia (Heidelberg, Germany) · 2023Article
- Triple-Network Dysconnectivity in Patients With First-Episode Psychosis and Individuals at Clinical High Risk for Psychosis.Psychiatry investigation · 2022Article
- Article
- Relationship between plasma clozapine/N-desmethylclozapine and changes in basal forebrain-dorsolateral prefrontal cortex coupling in treatment-resistant schizophrenia.Schizophrenia research · 2022Article
- A Novel Constrained Non-negative Matrix Factorization Method for Group Functional Magnetic Resonance Imaging Data Analysis of Adult Attention-Deficit/Hyperactivity Disorder.Frontiers in neuroscience · 2022Article
- Aberrant triple-network connectivity patterns discriminate biotypes of first-episode medication-naive schizophrenia in two large independent cohorts.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2021Article
Corrections and comments
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Authors and funding
9 authors.
Funding
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Abstract
The neuroimaging literature provides compelling evidence for functional dysconnectivity in people with psychosis. However, it is likely that at least some of the observed alterations represent secondary effects of illness chronicity and/or antipsychotic medication. In addition, the extent to which these alterations are specific to psychosis or represent a transdiagnostic feature of psychiatric illness remains unclear. The aim of this study was therefore to examine the diagnostic specificity of functional dysconnectivity in drug-naïve first-episode psychosis (FEP). We used resting-state functional magnetic resonance imaging and functional connectivity analysis to estimate network-level connectivity in 50 patients with FEP, 50 patients with major depressive disorder (MDD), 50 patients with post-traumatic stress disorder (PTSD), and 122 healthy controls (HCs). The FEP, MDD, and PTSD groups showed reductions in intranetwork connectivity of the default mode network relative to the HC group (p<0.05 corrected); therefore, intranetwork alterations were expressed across the three diagnostic groups. In addition, the FEP group showed heightened internetwork connectivity between the default mode network, particularly the anterior cingulate cortex, and the central executive network relative to the MDD, PTSD, and HC groups (p<0.05 corrected); therefore, internetwork alterations were specific to the FEP. These findings suggest that network-level alterations are present in individuals with a first episode of psychosis who have not been exposed to antipsychotic medication. In addition, they suggest a dissociation between aberrant internetwork connectivity as a distinctive feature of psychosis and aberrant intranetwork connectivity as a transdiagnostic feature of psychiatric illness.
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