Evidence map›Paper›PMID 27782075›Full record

ArticleInternational journal of molecular sciences2016

Association Analysis of Noncoding Variants in Neuroligins 3 and 4X Genes with Autism Spectrum Disorder in an Italian Cohort.

Martina Landini, Ivan Merelli, M Elisabetta Raggi, Nadia Galluccio, Francesca Ciceri, Arianna Bonfanti, Serena Camposeo, Angelo Massagli, Laura Villa, Erika Salvi and 5 more

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 20 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Article
  5. Article
  6. Article
  7. International journal of molecular sciences · 2019
    Review
  8. Article
  9. Review
  10. Article
  11. Significance of neurexin and neuroligin polymorphisms in regulating risk of Hirschsprung's disease.Journal of investigative medicine : the official publication of the American Federation for Clinical Research · 2018
    Article
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 4 institutions in 1 country.

Martina LandiniInstitute of Biomedical Technologies, National Research Council, Via Fratelli Cervi 93, 20090 Segrate, Italy. landinimartina@gmail.com.
Ivan MerelliInstitute of Biomedical Technologies, National Research Council, Via Fratelli Cervi 93, 20090 Segrate, Italy. ivan.merelli@itb.cnr.it.
M Elisabetta RaggiScientific Institute, IRCSS Eugenio Medea, 23842 Bosisio Parini, Italy. mariaelisabetta.raggi@bp.lnf.it.
Nadia GalluccioInstitute of Biomedical Technologies, National Research Council, Via Fratelli Cervi 93, 20090 Segrate, Italy. nadiagalluccio@gmail.com.
Francesca CiceriScientific Institute, IRCSS Eugenio Medea, 23842 Bosisio Parini, Italy. francesca.ciceri@bp.lnf.it.
Arianna BonfantiScientific Institute, IRCSS Eugenio Medea, 23842 Bosisio Parini, Italy. arianna.bonfanti@bp.lnf.it.
Serena CamposeoScientific Institute, IRCSS Eugenio Medea, 72100 Brindisi, Italy. serena.camposeo@libero.it.
Angelo MassagliScientific Institute, IRCSS Eugenio Medea, 72100 Brindisi, Italy. angelo.massagli@gmail.com.
Laura VillaScientific Institute, IRCSS Eugenio Medea, 23842 Bosisio Parini, Italy. laura.villa@bp.lnf.it.
Erika SalviDepartment of Health Sciences, University of Milan, 20142 Milan, Italy. erika.salvi@unimi.it.
Daniele CusiInstitute of Biomedical Technologies, National Research Council, Via Fratelli Cervi 93, 20090 Segrate, Italy. daniele.cusi@unimi.it.
Massimo MolteniScientific Institute, IRCSS Eugenio Medea, 23842 Bosisio Parini, Italy. massimo.molteni@bp.lnf.it.
Luciano MilanesiInstitute of Biomedical Technologies, National Research Council, Via Fratelli Cervi 93, 20090 Segrate, Italy. luciano.milanesi@itb.cnr.it.
Anna MarabottiScientific Institute, IRCSS Eugenio Medea, 23842 Bosisio Parini, Italy. amarabotti@unisa.it.
Alessandra MezzelaniInstitute of Biomedical Technologies, National Research Council, Via Fratelli Cervi 93, 20090 Segrate, Italy. alessandra.mezzelani@itb.cnr.it.
IRCCS Eugenio Medea · ITInstitute of Biomedical Technologies · ITUniversity of Milan · ITUniversity of Salerno · IT

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Since involved in synaptic transmission and located on X-chromosome, neuroligins 3 and 4X have been studied as good positional and functional candidate genes for autism spectrum disorder pathogenesis, although contradictory results have been reported. Here, we performed a case-control study to assess the association between noncoding genetic variants in

Indexed as

Genetic Predisposition to DiseasePolymorphism, Single NucleotideAllelesAutism Spectrum DisorderCase-Control StudiesCell Adhesion Molecules, NeuronalChildChild, PreschoolFemaleGene ExpressionGene FrequencyGenetic Association StudiesHaplotypesHumansItalyMaleCell Adhesion Molecules, NeuronalMembrane ProteinsNerve Tissue Proteinsneuroligin 3NLGN4X protein, humanautismgeneticshaplotype analysisneuroliginsnoncoding regionsSNPs

Identifiers

PMID27782075
PMCPMC5085789
OpenAlexW2537356164

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.