ArticlePediatric blood & cancer2017
Characteristics and outcomes in children with undifferentiated embryonal sarcoma of the liver: A report from the National Cancer Database.
Article in Pediatric blood & cancer, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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49 citing papers in PubMed, 90 citations in OpenAlex.
- Liver transplantation for pediatric liver tumors: a case report of hepatic angiosarcoma with literature review.Quantitative imaging in medicine and surgery · 2026Article
- Non-hepatoblastoma pediatric liver tumors: Unravelling of a lesser-known entity.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Article
- Primary non-hepatoblastoma liver tumors in children-Defining the profile of a very rare subset of childhood tumors.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026Article
- Undifferentiated embryonal sarcoma of the liver with a novel MAD1L1::ERG fusion: a 20-year survival case report.Virchows Archiv : an international journal of pathology · 2026Article
- Undifferentiated embryonal sarcoma of the liver presenting as a complex mixed solid-cystic hepatic lesion in a young adult: A case report.Radiology case reports · 2026Article
- Massive undifferentiated embryonal sarcoma: An unusual primary hepatic malignancy.Radiology case reports · 2025Article
- A journey full of surprises: surgical insights from pediatric undifferentiated embryonal liver sarcomas.Pediatric surgery international · 2025Article
- Mesenchymal Tumors of the Liver: An Update Review.Biomedicines · 2025Review
- "Update on pediatric primary liver tumors".Virchows Archiv : an international journal of pathology · 2025Review
- Undifferentiated high-grade sarcoma with UES-like features in the retroperitoneum: a Case Report with TP53 p.R306 mutation.Frontiers in oncology · 2025Article
- Case Report: Undifferentiated embryonic sarcoma of an adult liver.Frontiers in oncology · 2025Article
- Article
- Undifferentiated embryonal sarcoma of the liver in children: our experience in four difficult cases and three-dimensional practical exploration.World journal of surgical oncology · 2024Article
- Management of undifferentiated embryonal sarcoma of the liver: A Pediatric Surgical Oncology Research Collaborative study.Pediatric blood & cancer · 2024Article
- Undifferentiated embryonal sarcoma of the liver in pediatric patients: a single-institution retrospective case series.Translational pediatrics · 2024Article
- Patient Characteristics, Treatment, and Survival in Pleuropulmonary Blastoma: An Analysis from the National Cancer Database.Children (Basel, Switzerland) · 2024Article
- Review
- Review on Pediatric Malignant Focal Liver Lesions with Imaging Evaluation: Part II.Diagnostics (Basel, Switzerland) · 2023Review
- Update on the Pathology of Pediatric Liver Tumors: A Pictorial Review.Diagnostics (Basel, Switzerland) · 2023Review
- Undifferentiated embryonal sarcoma of the liver: a case report of a rare case in an adult patient.Journal of surgical case reports · 2023Article
Corrections and comments
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Authors and funding
12 authors at 9 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo examine patient characteristics and outcomes in children with undifferentiated embryonal sarcoma of the liver (UESL) using a multi-institutional database. SUMMARY BACKGROUND DATA: UESL is a rare disease (incidence is one per million). Therefore, the current literature is mostly limited to small case series.
methodsThe National Cancer Database was queried for primary UESL diagnosed between 1998 and 2012.
resultsA total of 103 patients (<18 years) were identified. The 5-year overall survival of the entire group was 86%. The best outcomes were seen in children who had tumors smaller than 15 cm and were able to undergo surgical resection with or without chemotherapy. Margin status did not appear to significantly affect survival. The most common type of resection was hemihepatectomy (37%), followed by sectionectomy (10%) and trisectionectomy (10%). Orthotopic liver transplant was performed in 10 children, all of whom survived to 5 years.
conclusionSurgical resection with or without chemotherapy should be the mainstay of treatment in children with UESL, and is associated with very favorable outcomes. Negative surgical margins were not associated with improved survival. Orthotopic liver transplantation may be a viable method of attaining local control in tumors, which would otherwise be unresectable.
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