Observational studyBrain and behavior2016
Prognostic value of plasma galectin-3 levels after aneurysmal subarachnoid hemorrhage.
Observational study in Brain and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 25 citations in OpenAlex.
- tRF-AspGTC Promotes Intracranial Aneurysm Formation by Controlling TRIM29-Mediated Galectin-3 Ubiquitination.Research (Washington, D.C.) · 2025Article
- Acute-Phase Plasma Pigment Epithelium-Derived Factor Predicting Outcomes after Aneurysmal Subarachnoid Hemorrhage in the Elderly.International journal of molecular sciences · 2024Article
- Biomarkers in aneurysmal subarachnoid hemorrhage: A short review.World neurosurgery: X · 2023Review
- Microglia activation, classification and microglia-mediated neuroinflammatory modulators in subarachnoid hemorrhage.Neural regeneration research · 2022Review
- Galectin-3 Involvement in Cognitive Processes for New Therapeutic Considerations.Frontiers in cellular neuroscience · 2022Review
- Galectin-3: A Novel Marker for the Prediction of Stroke Incidence and Clinical Prognosis.Mediators of inflammation · 2022Review
- Biomarkers Utility: At the Borderline between Cardiology and Neurology.Journal of cardiovascular development and disease · 2021Review
- The serum galectin-3 levels are associated with the severity and prognosis of ischemic stroke.Aging · 2021Article
- Mechanisms of neuroinflammation and inflammatory mediators involved in brain injury following subarachnoid hemorrhage.Histology and histopathology · 2020Review
- Galectin-3 as a Next-Generation Biomarker for Detecting Early Stage of Various Diseases.Biomolecules · 2020Review
- Biospecimens and Molecular and Cellular Biomarkers in Aneurysmal Subarachnoid Hemorrhage Studies: Common Data Elements and Standard Reporting Recommendations.Neurocritical care · 2019Article
- Galectins in the Pathogenesis of Cerebrovascular Accidents: An Overview.Journal of experimental neuroscience · 2019Review
- Role of Damage Associated Molecular Pattern Molecules (DAMPs) in Aneurysmal Subarachnoid Hemorrhage (aSAH).International journal of molecular sciences · 2018Review
- Possible Role of Inflammation and Galectin-3 in Brain Injury after Subarachnoid Hemorrhage.Brain sciences · 2018Review
- Galectin-3 as a novel biomarker for disease diagnosis and a target for therapy (Review).International journal of molecular medicine · 2018Review
- Galectin-3 and risk of ischaemic stroke: Reasons for Geographic and Racial Differences in Stroke cohort.European journal of neurology · 2017Article
- Serum galectin-3 levels and delirium among postpartum intensive care unit women.Brain and behavior · 2017Observational
- Prognostic value of plasma galectin-3 levels after aneurysmal subarachnoid hemorrhage.Brain and behavior · 2016Observational
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundInflammatory responses are correlated with secondary brain injury after aneurysmal subarachnoid hemorrhage (aSAH). Galectin-3 (Gal-3) is a novel biomarker reflecting inflammation status, and its elevated circulating levels are associated with poor prognosis of some inflammatory diseases. The aim of this study was to evaluate the relationship between Gal-3 plasma levels and prognosis in a group of aSAH patients. MATERIALS AND
methodsWe assessed plasma Gal-3 levels in 120 patients and 120 healthy individuals. 6-month clinical outcomes included mortality and unfavorable outcome (Glasgow Outcome Scale score of 1-3). Associations of plasma Gal-3 levels with clinical outcomes were investigated using multivariate analysis.
resultsPatients showed significantly higher Gal-3 levels as compared to controls. Circulating Gal-3 was significantly and independently associated with 6-month clinical outcomes in the logistic regression analysis. Moreover, we observed a significant correlation between circulating Gal-3 and World Federation of Neurological Surgeons scores and modified Fisher scores. Furthermore, Gal-3 possessed high area under receiver operating characteristic curve for prognostic assessment.
conclusionOur findings indicate the associations between Gal-3 levels and the severity and poor prognosis following aSAH. This suggests the possible role of Gal-3 in the prognostic prediction after aSAH.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.