Evidence map›Paper›PMID 27781146›Full record

ArticleBrain and behavior2016

Prevalence and impact of autoimmune thyroid disease on myasthenia gravis course.

Justyna Kubiszewska, Beata Szyluk, Piotr Szczudlik, Zbigniew Bartoszewicz, Małgorzata Dutkiewicz, Maksymilian Bielecki, Tomasz Bednarczuk, Anna Kostera-Pruszczyk

Open access · goldAbstract read
In one paragraph

Article in Brain and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
3.1field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 45 citations in OpenAlex.

  1. Article
  2. Evaluation of nonmotor symptoms in myasthenia gravis patients.Turkish journal of medical sciences · 2025
    Article
  3. Article
  4. Myasthenia gravis and nutrition.Frontiers in nutrition · 2025
    Review
  5. Clinical characteristics and therapeutic effect of myasthenia gravis coexisting with thyroid eye disease.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Review
  10. Lower BAFF Levels in Myasthenic Patients Treated with Glucocorticoids.Archivum immunologiae et therapiae experimentalis · 2021
    Article
  11. Article
  12. Article
  13. Article
  14. Review
  15. Review
  16. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Justyna KubiszewskaDepartment of Neurology Medical University of Warsaw Warsaw Poland.
Beata SzylukDepartment of Neurology Medical University of Warsaw Warsaw Poland.
Piotr SzczudlikDepartment of Neurology Medical University of Warsaw Warsaw Poland.
Zbigniew BartoszewiczDepartment of Internal Medicine and Endocrinology Medical University of Warsaw Warsaw Poland.
Małgorzata DutkiewiczDepartment of Immunology, Biochemistry and Nutrition Medical University of Warsaw Warsaw Poland.
Maksymilian BieleckiDepartment of Psychology SWPS University of Social Sciences and Humanities Warsaw Poland.
Tomasz BednarczukDepartment of Internal Medicine and Endocrinology Medical University of Warsaw Warsaw Poland.
Anna Kostera-PruszczykDepartment of Neurology Medical University of Warsaw Warsaw Poland.
Medical University of Warsaw · PLUniwersytet SWPS · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectivesAutoimmune thyroid diseases (ATDs) frequently accompany myasthenia gravis (MG) and may influence its course. We aimed to determine the association and impact of ATD with early- (<50 years), late-onset MG, or thymoma-MG. MATERIALS AND

methodsPrevalence of ATD was measured in a cross-sectional study of 343 consecutive patients with MG (236 F, 107 M) aged 4-89 years; 83.8% were seropositive, in 2.9%, anti-MuSK antibodies were detected. Concentrations of antithyroid peroxidase antibodies, antithyroglobulin antibodies, antithyrotropin receptor antibodies, and TSH level were measured in all patients. MG clinical course, treatment received, and treatment results were evaluated.

resultsAutoimmune thyroid diseases were diagnosed in 92 (26.8%) of MG patients including 4.4% with Graves (GD), 9% with Hashimoto thyroiditis (HT), and 13.4% with antithyroid antibodies only. GD patients had ocular symptoms more often than patients with antithyroid antibodies or HT (

conclusionsAutoimmune thyroid diseases are frequently accompanied by early-and late-onset MG, while thymoma-MG is related to higher risk of non-ATD. Myasthenia coexisting with ATD follows milder course than MG alone.

Indexed as

AdolescentAdultAgedAged, 80 and overAge of OnsetAutoantibodiesChildChild, PreschoolCross-Sectional StudiesDisease ProgressionFemaleHumansMaleMiddle AgedMyasthenia GravisPrevalenceAutoantibodiesautoimmune thyroid diseasesGraves’ diseaseHashimoto's thyroiditismyasthenia gravis

Identifiers

PMID27781146
PMCPMC5064344
OpenAlexW2498470030

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.