Evidence map›Paper›PMID 27781144›Full record

ArticleBrain and behavior2016

Socioeconomic status, white matter, and executive function in children.

Alexandra Ursache, Kimberly G Noble, Pediatric Imaging, Neurocognition and Genetics Study

Abstract read
In one paragraph

Article in Brain and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 104 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
104citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

104 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Socioeconomic Status Disparities in Children's Cognition-Differences in Degree or Kind?Perspectives on psychological science : a journal of the Association for Psychological Science · 2026
    Pooled it
  2. Pooled it
  3. Neural correlates of socioeconomic status in early childhood: a systematic review of the literature.Child neuropsychology : a journal on normal and abnormal development in childhood and adolescence · 2021
    Pooled it
  4. Impact of an Individualized Cognitive Training Intervention in Preschoolers from Poor Homes.International journal of environmental research and public health · 2020
    Trial
  5. Article
  6. Article
  7. Review
  8. White matter reflects the childhood exposome.bioRxiv : the preprint server for biology · 2026
    Article
  9. Article
  10. Prenatal Adversity and Neonatal Brain Connectivity Relate to Emerging Executive Function at Age 2 Years.Journal of the American Academy of Child and Adolescent Psychiatry · 2026
    Article
  11. Article
  12. Article
  13. Social Determinants of Health, the developing brain, and risk and resilience for psychopathology.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
    Review
  14. Article
  15. Review
  16. Article
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  20. Whole-brain white matter variation across childhood environments.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article

44 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Alexandra UrsacheSergievsky Center Columbia University New York City NY USA.ORCID 0000-0002-9621-6919
Kimberly G NobleTeachers College Columbia University New York City NY USA.
Pediatric Imaging, Neurocognition and Genetics Study

Funding

Creating a Pediatric Imaging-Genomics Data ResourceRC2DA029475 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI CHANG, LINDA, DALE, ANDERS M · 2009 to 2011
$9.1M
NEUROEPIDEMIOLOGY TRAINING PROGRAMT32NS007153 · NINDS · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI GU, YIAN, WILLEY, JOSHUA ZEBADIAH · 1987 to 2023
$6.2M
NIDA NIH HHS RC2 DA029475NINDS NIH HHS T32 NS007153
6 · The paper itself

Abstract

backgroundA growing body of evidence links socioeconomic status (SES) to children's brain structure. Few studies, however, have specifically investigated relations of SES to white matter structure. Further, although several studies have demonstrated that family SES is related to development of brain areas that support executive functions (EF), less is known about the role that white matter structure plays in the relation of SES to EF. One possibility is that white matter differences may partially explain SES disparities in EF (i.e., a mediating relationship). Alternatively, SES may differentially shape brain-behavior relations such that the relation of white matter structure to EF may differ as a function of SES (i.e., a moderating relationship).

methodIn a diverse sample of 1082 children and adolescents aged 3-21 years, we examined socioeconomic disparities in white matter macrostructure and microstructure. We further investigated relations between family SES, children's white matter volume and integrity in tracts supporting EF, and performance on EF tasks.

resultsSocioeconomic status was associated with fractional anisotropy (FA) and volume in multiple white matter tracts. Additionally, family income moderated the relation between white matter structure and cognitive flexibility. Specifically, across multiple tracts of interest, lower FA or lower volume was associated with reduced cognitive flexibility among children from lower income families. In contrast, children from higher income families showed preserved cognitive flexibility in the face of low white matter FA or volume. SES factors did not mediate or moderate links between white matter and either working memory or inhibitory control.

conclusionsThis work adds to a growing body of literature suggesting that the socioeconomic contexts in which children develop not only shape cognitive functioning and its underlying neurobiology, but may also shape the relations between brain and behavior.

Indexed as

Executive FunctionSocial ClassAdolescentBrainChildChild, PreschoolDiffusion Magnetic Resonance ImagingFemaleHumansMaleNeuropsychological TestsOrgan SizeRacial GroupsWhite Matteradolescentschildreneducationexecutive functionincomewhite matter

Identifiers

PMID27781144
PMCPMC5064342

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.