ArticleBrain and behavior2016
Altered regional brain function in the treatment-naive patients with somatic symptom disorder: a resting-state fMRI study.
Article in Brain and behavior, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
8 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Structural alterations in functional neurological disorder and related conditions: a software and hardware problem?NeuroImage. Clinical · 2019Pooled it
- Functional brain abnormalities in patients with somatic symptom disorder presenting with chest pain: a resting-state fMRI study.Scientific reports · 2026Article
- Somatic symptom disorder comorbidity in chronic cough: prevalence, clinical features, and neuroimaging characteristics.BMC pulmonary medicine · 2026Article
- A Longitudinal Study on Attenuated Structural Covariance in Patients With Somatic Symptom Disorder.Frontiers in psychiatry · 2022Article
- Abnormal Voxel-Wise Degree Centrality in Patients With Late-Life Depression: A Resting-State Functional Magnetic Resonance Imaging Study.Frontiers in psychiatry · 2019Article
- Somatic symptoms disorders in Parkinson's disease are related to default mode and salience network dysfunction.NeuroImage. Clinical · 2019Article
- Bidirectional Causal Connectivity in the Cortico-Limbic-Cerebellar Circuit Related to Structural Alterations in First-Episode, Drug-Naive Somatization Disorder.Frontiers in psychiatry · 2018Article
- Altered regional brain function in the treatment-naive patients with somatic symptom disorder: a resting-state fMRI study.Brain and behavior · 2016Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionSomatic symptom disorder (SSD) is an illness that occurs over a long time and results in significant disruption in daily life. Clinically, SSD patients typically express complaints that involve a variety of organ systems. However, the neural mechanism of SSD remains poorly understood.
methodsUsing resting-state functional magnetic resonance imaging, we investigated the characteristics of the regional basal brain function during resting state in patients with SSD. Eleven treatment-naïve SSD patients and 12 age-matched healthy controls were recruited in this study. Between-group differences in regional homogeneity values were analyzed.
resultsCompared with the healthy control group, the SSD group showed significant increases in regional homogeneity values in the right medial prefrontal cortex, anterior cingulate cortex and supramarginal gyrus, and significant decreases in the bilateral middle occipital gyrus, superior occipital gyrus and right cuneus and left postcentral gyrus and cerebellum. Meanwhile, the regional homogeneity value of the right medial prefrontal cortex positively correlated with the total duration of SSD.
conclusionsThe abnormal resting-state patterns in regional brain activity may contribute to understanding the mechanism of SSD.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.