Evidence map›Paper›PMID 27781109›Full record

ArticleJournal of virus eradication2016

Highlights of the Global HIV-1 CSF Escape Consortium Meeting, 9 June 2016, Bethesda, MD, USA.

Jeymohan Joseph, Paola Cinque, Deborah Colosi, Ameet Dravid, Luminita Ene, Howard Fox, Dana Gabuzda, Magnus Gisslen, Sarah Beth Joseph, Scott Letendre and 12 more

Abstract readEditorial
In one paragraph

Article in Journal of virus eradication, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.

0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

29 citing papers in PubMed.

  1. Trial
  2. Article
  3. Article
  4. Article
  5. Review
  6. Article
  7. Flavonoids as Potential Natural Compounds for the Prevention and Treatment of Eczema.Anti-inflammatory & anti-allergy agents in medicinal chemistry · 2024
    Review
  8. Article
  9. Article
  10. Review
  11. Review
  12. CNS Neurotoxicity of Antiretrovirals.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2021
    Review
  13. SARS-CoV-2 infection does not induce HIV viral escape in the central nervous system: A case series.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2020
    Article
  14. Article
  15. Observational
  16. Review
  17. Observational
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors.

Jeymohan JosephDivision of AIDS Research , National Institute of Mental Health, National Institutes of Health , Bethesda , MD , USA.
Paola CinqueDepartment of Infectious Diseases , IRCCS San Raffaele Scientific Institute , Milan , Italy.
Deborah ColosiDivision of AIDS Research , National Institute of Mental Health, National Institutes of Health , Bethesda , MD , USA.
Ameet DravidDepartment of HIV Medicine , Ruby Hall Clinic , Pune , India.
Luminita EneDepartment of Infectious Diseases , 'Dr Victor Babes' Hospital for Infectious and Tropical Diseases , Bucharest , Romania.
Howard FoxDepartment of Pharmacology and Experimental Neuroscience , University of Nebraska Medical Center , Omaha , NE , USA.
Dana GabuzdaDepartment of Cancer Immunology and Virology , Dana-Farber Cancer Institute , Boston , MA , USA.
Magnus GisslenDepartment of Infectious Diseases , Sahlgrenska Academy , University of Gothenburg , Gothenburg , Sweden.
Sarah Beth JosephDepartment of Microbiology and Immunology , University of North Carolina at Chapel Hill , Chapel Hill , NC , USA .
Scott LetendreDepartment of Medicine , University of California , San Diego , CA , USA.
Shibani S MukerjiDepartment of Cancer Immunology and Virology, Dana-Farber Cancer Institute, Boston, MA, USA; Department of Neurology, Massachusetts General Hospital, Boston, MA, USA.
Avindra NathSection of Infections of the Nervous System , National Institute of Neurological Diseases and Stroke , National Institutes of Health , Bethesda , MD , USA.
Ignacio Perez-ValeroDepartment of Internal Medicine - HIV Unit , Hospital La Paz-IdiPAZ , Madrid , Spain .
Deborah PersaudJohns Hopkins University School of Medicine & Bloomberg School of Public Health , Baltimore , MD , USA.
Richard W PriceDepartment of Neurology , University of California , San Francisco , CA , USA.
Vasudev R RaoDivision of AIDS Research , National Institute of Mental Health, National Institutes of Health , Bethesda , MD , USA.
Ned SacktorDepartment of Neurology , Johns Hopkins University , Baltimore , MD , USA.
Ronald SwanstromDepartment of Microbiology and Immunology , University of North Carolina at Chapel Hill , Chapel Hill , NC , USA .
Alan WinstonDivision of Infectious Diseases , Imperial College London , London , UK.
Valerie WojnaDivision of Neurology , University of Puerto Rico-Medical Sciences Campus , San Juan , PR , USA.
Edwina WrightDepartment of Infectious Diseases , Alfred Health , Melbourne , Australia.
Serena SpudichDepartment of Neurology , Yale University , New Haven , CT , USA.

Funding

Neuropathogenesis of Retroviral InfectionsZIANS003130 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI NATH, AVINDRA · 2011 to 2025
$73.7M
STRUCTURAL NEUROIMAGING COREP30MH062512 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI DAVID J MOORE · 2001 to 2026
$50.4M
Translational Methamphetamine AIDS Research Center (TMARC)P50DA026306 · NIDA · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI GRANT, IGOR · 2009 to 2018
$33.9M
California NeuroAIDS Tissue NetworkU24MH100928 · NIMH · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI ACHIM, CRISTIAN L, MOORE, DAVID J · 2013 to 2023
$13.9M
NNTC Data Coordinating CenterU24MH100925 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI FOX, HOWARD S, SHERMAN, SETH · 2013 to 2022
$9.5M
Research Pilot Project ProgramP30GM106397 · NIGMS · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI JOHNSON, KEITH R · 2013 to 2017
$4.9M
Compartmentalized CSF viral escape and the CNS HIV reservoirR01NS094067 · NINDS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI PRICE, RICHARD W. · 2015 to 2020
$3.9M
NIDA NIH HHS P50 DA026306NIGMS NIH HHS P30 GM106397NIMH NIH HHS P30 MH062512NIMH NIH HHS U24 MH100925NIMH NIH HHS U24 MH100928NINDS NIH HHS R01 NS094067
6 · The paper itself

Abstract

CSF HIV escape is a recently recognised phenomenon that suggests that despite suppressive treatment, HIV RNA may be detected in the CNS compartment in some individuals. In rare cases this is associated with clinical neurological disease, while in most cases, neurological consequences are not apparent. Attempts at characterising the biological substrates of CSF escape and further investigating the neurological consequences need to be made to better understand the implications of this condition for the HIV cure agenda as well as for clinical outcomes. The Global CSF HIV-1 Escape Consortium meeting, convened by the US National Institute of Mental Health, was a first step to gather investigators from diverse sites to discuss opportunities for future collaborative work on this emerging issue. To better understand CSF HIV escape and allow cross-site data reconciliation, it will be useful to reach a consensus set of definitions of the distinct forms of CSF escape, without which concerted cross-site efforts are difficult.

Identifiers

PMID27781109
PMCPMC5075354

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.