Evidence map›Paper›PMID 27781077›Full record

ArticleOxidative medicine and cellular longevity2016

Neuroprotective Effects of Açaí (

Alencar Kolinski Machado, Ana Cristina Andreazza, Tatiane Morgana da Silva, Aline Augusti Boligon, Vanusa do Nascimento, Gustavo Scola, Angela Duong, Francine Carla Cadoná, Euler Esteves Ribeiro, Ivana Beatrice Mânica da Cruz

Registry-linked trialAbstract read
In one paragraph

Article in Oxidative medicine and cellular longevity, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04404218 (Randomized Clinical Trial of Açaí Palm Berry Extract as an Intervention in Patients Diagnosed With COVID-19), which is not on this map. Cited by 24 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04404218 phase2unknown statusnot on this mapstarted 2020, after this paper: background citation

Randomized Clinical Trial of Açaí Palm Berry Extract as an Intervention in Patients Diagnosed With COVID-19

TypeinterventionalSponsorUniversity Health Network, TorontoRan2020 to 2022Enrolled480ConditionsCOVIDArmsAçaí palm berry extract - natural product, Placebo
3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Trial
  3. Review
  4. Review
  5. Article
  6. Article
  7. Article
  8. Review
  9. Biology · 2024
    Article
  10. What We Know aboutNutrients · 2023
    Article
  11. Article
  12. Acai Berry (Life (Basel, Switzerland) · 2023
    Article
  13. Açaí (Nutrients · 2023
    Review
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Emerging Lipids from Arecaceae Palm Fruits in Brazil.Molecules (Basel, Switzerland) · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Alencar Kolinski MachadoPostgraduate Program of Pharmacology, Federal University of Santa Maria, Santa Maria, RS, Brazil; Biogenomics Laboratory, Department of Morphology, Health Science Center, Federal University of Santa Maria, Santa Maria, RS, Brazil.ORCID 0000-0003-2003-8420
Ana Cristina AndreazzaDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada; Centre for Addiction and Mental Health, Toronto, ON, Canada.
Tatiane Morgana da SilvaFederal University of Pelotas, Pelotas, RS, Brazil.
Aline Augusti BoligonPhytochemical Research Laboratory, Department of Industrial Pharmacy, Federal University of Santa Maria, Santa Maria, RS, Brazil.ORCID 0000-0001-5434-5037
Vanusa do NascimentoBiogenomics Laboratory, Department of Morphology, Health Science Center, Federal University of Santa Maria, Santa Maria, RS, Brazil; Third Age Open University, University of Amazonas State, Manaus, AM, Brazil.
Gustavo ScolaDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada; Centre for Addiction and Mental Health, Toronto, ON, Canada.ORCID 0000-0003-1554-9031
Angela DuongDepartment of Psychiatry, University of Toronto, Toronto, ON, Canada.
Francine Carla CadonáBiogenomics Laboratory, Department of Morphology, Health Science Center, Federal University of Santa Maria, Santa Maria, RS, Brazil; Postgraduate Program of Biological Sciences, Toxicological Biochemistry, Federal University of Santa Maria, Santa Maria, RS, Brazil.ORCID 0000-0002-6761-9743
Euler Esteves RibeiroBiogenomics Laboratory, Department of Morphology, Health Science Center, Federal University of Santa Maria, Santa Maria, RS, Brazil; Third Age Open University, University of Amazonas State, Manaus, AM, Brazil.
Ivana Beatrice Mânica da CruzPostgraduate Program of Pharmacology, Federal University of Santa Maria, Santa Maria, RS, Brazil; Biogenomics Laboratory, Department of Morphology, Health Science Center, Federal University of Santa Maria, Santa Maria, RS, Brazil; Postgraduate Program of Biological Sciences, Toxicological Biochemistry, Federal University of Santa Maria, Santa Maria, RS, Brazil.ORCID 0000-0003-3008-6899

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuropsychiatric diseases, such as bipolar disorder (BD) and schizophrenia (SCZ), have a very complex pathophysiology. Several current studies describe an association between psychiatric illness and mitochondrial dysfunction and consequent cellular modifications, including lipid, protein, and DNA damage, caused by cellular oxidative stress.

Indexed as

AntioxidantsCell Line, TumorDose-Response Relationship, DrugElectron Transport Complex IEuterpeFruitHumansLipid PeroxidationMitochondriaNADH DehydrogenaseNeuronsNeuroprotective AgentsOxidative StressPhytotherapyPlant ExtractsPlants, MedicinalAntioxidantsElectron Transport Complex INADH DehydrogenaseNDUFS7 protein, humanNDUFS8 protein, humanNeuroprotective AgentsPlant ExtractsReactive Oxygen SpeciesRotenoneUncoupling Agents

Identifiers

PMID27781077
PMCPMC5066013

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.