Evidence map›Paper›PMID 27781036›Full record

ArticleFrontiers in immunology2016

Modulation of Primary Immune Response by Different Vaccine Adjuvants.

Annalisa Ciabattini, Elena Pettini, Fabio Fiorino, Gabiria Pastore, Peter Andersen, Gianni Pozzi, Donata Medaglini

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 52 papers.

0numbers the graph read from it
0cells of the map it votes in
52citing papers in PubMed
4.0field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

52 citing papers in PubMed, 72 citations in OpenAlex.

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  14. Preclinical study of a DNA vaccine targeting SARS-CoV-2.Current research in translational medicine · 2022
    Article
  15. Review
  16. The Effect of Delivery Systems on the Induction of T Helper 1 Cell Response to an ESAT6-Like Protein Rv3619c and Identification of Its Immunodominant Peptides.Medical principles and practice : international journal of the Kuwait University, Health Science Centre · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 2 countries.

Annalisa CiabattiniLaboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of Siena , Siena , Italy.
Elena PettiniLaboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of Siena , Siena , Italy.
Fabio FiorinoLaboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of Siena , Siena , Italy.
Gabiria PastoreLaboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of Siena , Siena , Italy.
Peter AndersenDepartment of Infectious Disease Immunology, Statens Serum Institut , Copenhagen , Denmark.
Gianni PozziLaboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of Siena , Siena , Italy.
Donata MedagliniLaboratory of Molecular Microbiology and Biotechnology, Department of Medical Biotechnologies, University of Siena , Siena , Italy.
University of Siena · ITStatens Serum Institut · DK

Funding

NIAID NIH HHS HHSN272201300006C
6 · The paper itself

Abstract

Adjuvants contribute to enhancing and shaping the vaccine immune response through different modes of action. Here early biomarkers of adjuvanticity after primary immunization were investigated using four different adjuvants combined with the chimeric tuberculosis vaccine antigen H56. C57BL/6 mice were immunized by the subcutaneous route with different vaccine formulations, and the modulation of primary CD4

Indexed as

adjuvantsB cell primingCD4+ T cell primingMHC class II tetramers

Identifiers

PMID27781036
PMCPMC5066114
OpenAlexW2532652101

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.