ArticleInternational journal of obesity (2005)2017
Maternal obesity modulates intracellular lipid turnover in the human term placenta.
Article in International journal of obesity (2005), 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed, 87 citations in OpenAlex.
- Maternal obesity results in decreased syncytiotrophoblast synthesis of palmitoleic acid, a fatty acid with anti-inflammatory and insulin-sensitizing properties.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2019Trial
- Psychological and anthropometric outcomes in preschool children exposed to antenatal maternal obesity: modelling of early life risk factors.BMJ mental health · 2026Article
- Inflammation-Associated Transcriptional Remodeling of Antioxidant and Stress Signaling Pathways in First-Trimester Placenta in Maternal Overweight and Obesity.Biomolecules · 2026Article
- SLC27, solute carrier 27 family, a long-chain fatty acid membrane transporters, in human cancers.Frontiers in cell and developmental biology · 2026Review
- Maternal Plasma Choline Levels Are Positively Correlated with Maternal and Placental Phospholipid-DHA Content in Females with Obesity Who Receive DHA Supplementation.The Journal of nutrition · 2025Article
- Association of gestational and childhood circulating C-peptide concentrations in the hyperglycemia and adverse pregnancy outcomes follow-up study.Diabetes research and clinical practice · 2025Article
- Placental Epigenome Impacts Fetal Development: Effects of Maternal Nutrients and Gut Microbiota.Nutrients · 2024Review
- Physically active pregnancies: Insights from the placenta.Physiological reports · 2024Review
- Maternal overweight and obesity and its association with metabolic changes and fetal overgrowth in the absence of gestational diabetes mellitus: A prospective cohort study.Acta obstetricia et gynecologica Scandinavica · 2024Article
- An Integrated Multi-OMICS Approach Highlights Elevated Non-Esterified Fatty Acids Impact BeWo Trophoblast Metabolism and Lipid Processing.Metabolites · 2023Article
- Made in the Womb: Maternal Programming of Offspring Cardiovascular Function by an Obesogenic Womb.Metabolites · 2023Review
- The lipase cofactor CGI58 controls placental lipolysis.JCI insight · 2023Article
- Obesity downregulates lipid metabolism genes in first trimester placenta.Scientific reports · 2022Article
- Review
- Human placental lipid content and lipid metabolic enzyme abundance in obesity and across gestation.Clinical science (London, England : 1979) · 2022Article
- Maternal Lipid Metabolism Is Associated With Neonatal Adiposity: A Longitudinal Study.The Journal of clinical endocrinology and metabolism · 2022Article
- Serine Hydrolases in Lipid Homeostasis of the Placenta-Targets for Placental Function?International journal of molecular sciences · 2022Review
- Programming of cardiometabolic health: the role of maternal and fetal hyperinsulinaemia.The Journal of endocrinology · 2022Review
- Placental Nutrient Transporters and Maternal Fatty Acids in SGA, AGA, and LGA Newborns From Mothers With and Without Obesity.Frontiers in cell and developmental biology · 2022Article
- Association between the levels of CGI-58 and lipoprotein lipase in the placenta of patients with preeclampsia.Experimental and therapeutic medicine · 2021Article
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Authors and funding
11 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundObesity before pregnancy is associated with impaired metabolic status of the mother and the offspring later in life. These adverse effects have been attributed to epigenetic changes in utero, but little is known about the role of placental metabolism and its contribution to fetal development.
objectivesWe examined the impact of maternal pre-pregnancy obesity on the expression of genes involved in placental lipid metabolism in lean and obese women. SUBJECTS/
methodsSeventy-three lean and obese women with healthy pregnancy were recruited at term elective cesarean delivery. Metabolic parameters were measured on maternal venous blood samples. Expression of 88 genes involved in lipid metabolism was measured in whole placenta tissue. Proteins of genes differently expressed in response to maternal obesity were quantified, correlated with maternal parameters and immunolocalized in placenta sections. Isolated primary trophoblasts were used for in vitro assays.
resultsTriglyceride (TG) content was increased in placental tissue of obese (1.10, CI 1.04-1.24 mg g
conclusionPre-gravid obesity significantly modifies the expression of placental genes related to transport and storage of neutral lipids. We propose that the upregulation of CGI-58, a master regulator of TG hydrolysis, contributes to the turnover of intracellular lipids in placenta of obese women, and is tightly regulated by metabolic factors of the mother.
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