ArticlePlant physiology2016
An E3 Ligase Affects the NLR Receptor Stability and Immunity to Powdery Mildew.
Article in Plant physiology, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 43 citations in OpenAlex.
- A semi-dominant NLR allele regulates growth and disease resistance in wheat.Plant biotechnology journal · 2025Article
- Mapping of resistance genes to powdery mildew based on DNA re-sequencing and bulk segregant analysis in Capsicum.Protoplasma · 2025Article
- The receptor-like cytoplasmic kinase OsBSK1-2 regulates immunity via an HLH/bHLH complex.Journal of integrative plant biology · 2024Article
- Proteolysis in plant immunity.The Plant cell · 2024Review
- A viral effector blocks the turnover of a plant NLR receptor to trigger a robust immune response.The EMBO journal · 2024Article
- Advances in Biological Control and Resistance Genes of Brassicaceae Clubroot Disease-The Study Case of China.International journal of molecular sciences · 2023Review
- Emerging roles of the ubiquitin-proteasome pathway in enhancing crop yield by optimizing seed agronomic traits.Plant cell reports · 2022Review
- An interolog-based barley interactome as an integration framework for immune signaling.Genetics · 2022Article
- Expression Patterns and Functional Analysis of 11 E3 Ubiquitin Ligase Genes in Rice.Frontiers in plant science · 2022Article
- Transcription FactorPlants (Basel, Switzerland) · 2021Article
- Next-generation yeast-two-hybrid analysis with Y2H-SCORES identifies novel interactors of the MLA immune receptor.PLoS computational biology · 2021Article
- The ubiquitin system affects agronomic plant traits.The Journal of biological chemistry · 2020Review
- Plant E3 ligases SNIPER1 and SNIPER2 broadly regulate the homeostasis of sensor NLR immune receptors.The EMBO journal · 2020Article
- Plant NLRs: The Whistleblowers of Plant Immunity.Plant communications · 2020Review
- Article
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Following the detection of pathogen cognate effectors, plant Nod-like receptors (NLRs) trigger isolate-specific immunity that is generally associated with cell death. The regulation of NLR stability is important to ensure effective immunity. In barley (Hordeum vulgare), the allelic Mildew locus A (MLA) receptors mediate isolate-specific disease resistance against powdery mildew fungus (Blumeria graminis f. sp. hordei). Currently, how MLA stability is controlled remains unknown. Here, we identified an MLA-interacting RING-type E3 ligase, MIR1, that interacts with several MLAs. We showed that the carboxyl-terminal TPR domain of MIR1 mediates the interaction with the coiled-coil domain-containing region of functional MLAs, such as MLA1, MLA6, and MLA10, but not with that of the nonfunctional MLA18-1. MIR1 can ubiquitinate the amino-terminal region of MLAs in vitro and promotes the proteasomal degradation of MLAs in vitro and in planta. Both proteasome inhibitor treatment and virus-induced gene silencing-mediated MIR1 silencing significantly increased MLA abundance in barley transgenic lines. Furthermore, overexpression of MIR1 specifically compromised MLA-mediated disease resistance in barley, while coexpression of MIR1 and MLA10 attenuated MLA10-induced cell death signaling in Nicotiana benthamiana Together, our data reveal a mechanism for the control of the stability of MLA immune receptors and for the attenuation of MLA-triggered defense signaling by a RING-type E3 ligase via the ubiquitin proteasome system.
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