Evidence map›Paper›PMID 27780858›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2017

5T4-Targeted Therapy Ablates Cancer Stem Cells and Prevents Recurrence of Head and Neck Squamous Cell Carcinoma.

Samuel A Kerk, Kelsey A Finkel, Alexander T Pearson, Kristy A Warner, Zhaocheng Zhang, Felipe Nör, Vivian P Wagner, Pablo A Vargas, Max S Wicha, Elaine M Hurt and 3 more

Open access · bronzeAbstract read
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2017. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 53 citations in OpenAlex.

  1. Article
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  5. Regulating Lipid MetabolismRecent patents on anti-cancer drug discovery · 2025
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  15. Cancer stem cells in head and neck cancer.American journal of stem cells · 2021
    Review
  16. Article
  17. Article
  18. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 4 institutions in 2 countries.

Samuel A KerkDepartment of Cariology, Restorative Sciences, Endodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan.
Kelsey A FinkelDepartment of Cariology, Restorative Sciences, Endodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan.
Alexander T PearsonDepartment of Cariology, Restorative Sciences, Endodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan.
Kristy A WarnerDepartment of Cariology, Restorative Sciences, Endodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan.
Zhaocheng ZhangDepartment of Cariology, Restorative Sciences, Endodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan.
Felipe NörDepartment of Cariology, Restorative Sciences, Endodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan.
Vivian P WagnerDepartment of Oral Pathology, Federal University of Rio Grande do Sul, Porto Alegre, Brazil.
Pablo A VargasDepartment of Oral Diagnosis, University of Campinas, Piracicaba, Brazil.
Max S WichaDepartment of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan.
Elaine M HurtOncology Research, MedImmune, Gaithersburg, Maryland.
Robert E HollingsworthOncology Research, MedImmune, Gaithersburg, Maryland.
David A TiceOncology Research, MedImmune, Gaithersburg, Maryland.
Jacques E NörDepartment of Cariology, Restorative Sciences, Endodontics, University of Michigan School of Dentistry, Ann Arbor, Michigan. jenor@umich.edu.
University of Michigan · USAltimmune (United States) · USUniversidade Federal do Rio Grande do Sul · BRUniversidade Estadual de Campinas (UNICAMP) · BR

Funding

XenograftP30CA046592 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI THEODORE S LAWRENCE · 1988 to 2026
$178.2M
Therapeutic Potential and Mechanism of Action of Potent Small Molecule InhibitorsP50CA097248 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI WOLF, GREGORY T · 2002 to 2013
$25.3M
Salivary gland cancer stem cellsR01DE021139 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jacques Eduardo Nor · 2011 to 2026
$5.8M
Therapeutic Inhibition of MDM2/Bcl-2 in Pre-clinical Models of Adenoid Cystic CarR01DE023220 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI NOR, JACQUES EDUARDO · 2012 to 2015
$1.5M
A reasoned approach to combination therapy development in head and neck cancerK08DE026500 · NIDCR · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI PEARSON, ALEXANDER THOMAS · 2016 to 2020
$800k
NCI NIH HHS P30 CA046592NCI NIH HHS P50 CA097248NIDCR NIH HHS K08 DE026500NIDCR NIH HHS R01 DE021139NIDCR NIH HHS R01 DE023220
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AnimalsBenzodiazepinesCarcinoma, Squamous CellCell Line, TumorCell Self RenewalDNA DamageDrug Resistance, NeoplasmGene Expression Regulation, NeoplasticHead and Neck NeoplasmsHumansImmunoconjugatesMembrane GlycoproteinsMiceNeoplasm Recurrence, LocalNeoplastic Stem CellsPyrrolesBenzodiazepinesImmunoconjugatesMembrane GlycoproteinsPyrrolespyrrolo(2,1-c)(1,4)benzodiazepinetrophoblastic glycoprotein 5T4, human

Identifiers

PMID27780858
PMCPMC5405006
OpenAlexW2532521862

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.