Evidence map›Paper›PMID 27780829›Full record

ArticleCirculation research2016

Exposure to Fine Particulate Air Pollution Is Associated With Endothelial Injury and Systemic Inflammation.

C Arden Pope, Aruni Bhatnagar, James P McCracken, Wesley Abplanalp, Daniel J Conklin, Timothy O'Toole

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2016. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03314987 (Nucleophilic Defense Against PM Toxicity), which is not on this map. Cited by 322 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
322citing papers in PubMed, 2 pooled it
28.2field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT03314987 nacompletednot on this mapstarted 2018, after this paper: background citation

Nucleophilic Defense Against PM Toxicity

TypeinterventionalSponsorUniversity of LouisvilleRan2018 to 2022Enrolled299ConditionsAir Pollution ToxicityArmsL-carnosine, placebo
3 · Its place in the literature

Who cites it

322 citing papers in PubMed, 2 syntheses or guidelines pooled it, 674 citations in OpenAlex.

  1. Associations of exposure to PMBMC public health · 2025
    Pooled it
  2. Pooled it
  3. Trial
  4. Review
  5. Article
  6. Association between PMEuropean journal of pediatrics · 2026
    Article
  7. Review
  8. Article
  9. Review
  10. Review
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Uterine Vulnerability to Environmental PMInternational journal of molecular sciences · 2026
    Article
  19. Article
  20. The Green Heart Project: objectives, design, and methods.American journal of epidemiology · 2026
    Article

262 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

C Arden PopeFrom the Department of Economics, Brigham Young University, Provo, UT (C.A.P.); and Diabetes and Obesity Center, Division of Cardiovascular Medicine, Department of Medicine, University of Louisville, KY (A.B., J.P.M., W.A., D.J.C., T.O.). cap3@byu.edu.
Aruni BhatnagarFrom the Department of Economics, Brigham Young University, Provo, UT (C.A.P.); and Diabetes and Obesity Center, Division of Cardiovascular Medicine, Department of Medicine, University of Louisville, KY (A.B., J.P.M., W.A., D.J.C., T.O.).
James P McCrackenFrom the Department of Economics, Brigham Young University, Provo, UT (C.A.P.); and Diabetes and Obesity Center, Division of Cardiovascular Medicine, Department of Medicine, University of Louisville, KY (A.B., J.P.M., W.A., D.J.C., T.O.).
Wesley AbplanalpFrom the Department of Economics, Brigham Young University, Provo, UT (C.A.P.); and Diabetes and Obesity Center, Division of Cardiovascular Medicine, Department of Medicine, University of Louisville, KY (A.B., J.P.M., W.A., D.J.C., T.O.).
Daniel J ConklinFrom the Department of Economics, Brigham Young University, Provo, UT (C.A.P.); and Diabetes and Obesity Center, Division of Cardiovascular Medicine, Department of Medicine, University of Louisville, KY (A.B., J.P.M., W.A., D.J.C., T.O.).
Timothy O'TooleFrom the Department of Economics, Brigham Young University, Provo, UT (C.A.P.); and Diabetes and Obesity Center, Division of Cardiovascular Medicine, Department of Medicine, University of Louisville, KY (A.B., J.P.M., W.A., D.J.C., T.O.).
Brigham Young University · US

Funding

Project 5 - Metabolomic Analysis of AtherothrombosisP20GM103492 · NIGMS · UNIVERSITY OF LOUISVILLE · PI DEFILIPPIS, ANDREW · 2012 to 2017
$13.8M
Endothelial Progenitor Cells and Particulate Air PollutionR01ES019217 · NIEHS · UNIVERSITY OF LOUISVILLE · PI BHATNAGAR, ARUNI, O'TOOLE, TIMOTHY E · 2011 to 2022
$6.0M
NIEHS NIH HHS R01 ES019217NIGMS NIH HHS P20 GM103492
6 · The paper itself

Abstract

rationaleEpidemiological evidence indicates that exposures to fine particulate matter air pollution (PM

objectiveTo examine whether acute exposure to PM METHODS AND

resultsBlood was collected from healthy, nonsmoking, young adults during 3 study periods that included episodes of elevated PM

conclusionsEpisodic PM

Indexed as

AdultAir PollutionEndothelium, VascularEnvironmental ExposureFatty Acids, Omega-3FemaleHumansInflammationInflammation MediatorsMaleParticle SizeParticulate MatterRandom AllocationYoung AdultFatty Acids, Omega-3Inflammation MediatorsParticulate Matterair pollutioncardiovascular diseaseinflammationparticulate mattervascular disease

Identifiers

PMID27780829
PMCPMC5215745
OpenAlexW2534879302

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.